Engineering Seminar - "Molecular and Mechanical Regulation of Heart Valve Development." By Dr. Philip Buskohl, Materials Research Contractor for the Air Force Research Labs at Wright-Patterson Air Force Base, OH

November 16, 2012 | 3:00 PM |
VanderWerf 104

Congenital heart defects (CHD) affect over 1% of the American population and are the cause of substantial healthcare costs.  A majority of these defects involve malformations of the valvuloseptal apparatus, which is the precursor to the valves of the heart.  Current genetic evidence for CHDs inadequately explains the variety and prevalence of these defects, which suggests that misguided molecular signals and mechanical forces may be responsible.  In this study, we investigated how these aberrant cues may alter valve mechanical properties and valve morphology during embryonic development.  Molecularly, we focused on the capacity of transforming growth factor beta 3