Phone: 616-395-7306
Fax: 616-395-7125
E-mail: fraley@hope.edu

Scholastic Record:

B.S. 1984-89 University of Maryland at College Park (Animal Science/Emphasis on Physiology)

M.S. 1989-92 University of Maryland at College Park (Physiology/Emphasis on Neuroscience), Physiological Changes Within the Central Nervous System During Kinfe-cut or Biochemically Induced Sexual Precocity. Thesis Major Advisor: Professor Wayne J. Kuenzel

Ph.D. 1992-98 Washington State University at Pullman (Ph.D. Neuroscience), Postnatal Development of the Spinal Nucleus of the Bulbocavernosus in the Mongolian Gerbil: Effects of Peripubertal Gonadal hormones on Anatomy, Androgen Receptor, and Neurotrophin Receptor Expression. Dissertation Major Advisor: Associate Professor Catherine Ulibarri, Center for Neurosciences

Publications:

Fraley, G.S. and W.J. Kuenzel. 1993. The involvement of neuropeptide Y in the onset of puberty. Life Sciences 52: 1649-1656.

Fraley, G.S. and W.J. Kuenzel. 1993. Immunocytochemical and histochemical analyses of gonadotropin-releasing hormone, tyrosine hydroxylase, and cytochrome oxidase reactivity within the hypothalamus of chicks showing early sexual maturation. Histochemistry 99: 221-229.

Kuenzel, W.J. and G.S. Fraley. 1995. Neuropeptide Y: its role in the neural regulation of reproductive function and food intake in avian and mammalian species. Poultry Avian Biological Reviews 6(3): 185-209.

Horowiz, J.M., V.A. Vernace, J. Myers, M.K. Stachowiak, D. Hanlon, G.S. Fraley, and G. Torres. 2001. Parkin peptide analyses in vertebrate and invertebrate species by Western blotting and immunocytochemical methods. Journal of Chemical Neuroanatomy 21(1):75-93.

Fraley, G.S. and C. Ulibarri. 2001. Sexual dimorphism in the number and size of SNB motoneurons: delayed development during normal ontogeny. Developmental Brain Research 126(1):57-64

Fraley, G.S. and C. Ulibarri. 2002. Ontogeny of androgen receptor (AR) and p75 neurotrophin receptor mRNA during neonatal development and AR and p75 proteins during peripubertal development of the SNB in the Mongolian gerbil. Developmental Brain Research 137: 101-114.

Fraley, G.S. and C. Ulibarri. 2002. Long term castration effects motoneuron sixe but not number in the SNB of the adult male Mongolian gerbil. Brain Research. 953: 265-271

Fraley GS. 2002. Immunolesion of hindbrain catecholaminergic projections to the medial hypothalamus attenuates penile reflexive erections and alters hypothalamic RNA. J. Neuroendocrinoogy 14: 345-348.

Fraley, G.S. and S. Ritter. 2002. Immunotoxic lesion of catecholaminergic neurons innervating the medial hypothalamus elevates basal expression of and attenuates glucoprivation-induced increases in agouti gene-related protein (AGRP) mRNA. Peptides 6397: 1-8.

Fraley, G.S. and S. Ritter. 2003. Immunolesion of hindbrain catecholaminergic afferents to medial hypothalamus attenuates glucoprivic feeding and increases NPY and AGRP mRNA levels in the arcuate nucleus but has no effect on CRH mRNA levels in the paraventricular nucleus of the hypothalamus. Endocrinology 144(1): 75-83

Krasnow, S.M., G.S. Fraley, S.M. Schuh, J.W. Baumgartner, D.K. Clifton and R.A.Steiner. 2003. A Role For Galanin-like Peptide (GALP) in the integration of feeding, body weight regulation and reproduction in the mouse. Endocrinology 144(3): 813-822.

Fraley, G.S., I. Shimada, J. Baumgartner, D.K. Clifton, R.A. Steiner. 2003. Differential fos induction in the hypothalamus following intracerebroventricular injection of galanin-like peptide. Endocrinology 144(4): 1143-1146.

Hansen, K.R., S.M. Krasnow, M.A. Nolan, G.S. Fraley, J.W. Baumgartner, D.K. Clifton, and R.A. Steiner. Activation of the sympathetic nervous system by galanin-like peptide - a possible link between leptin and metabolism. Endocrinology 144: 4709-4717.

Fraley, G.S., I. Shimada, D. Teklemichael, J. Scarlett, D.K. Clifton, and R.A. Steiner. 2004. The effects of insulin and diabetes on hypothalamic galanin-like peptide mRNA. Diabetes 53: 1237-1242.

Fraley, G.S., S.E. Thomas-Smith, B. Acohido, D.K. Clifton, and R.A. Steiner. 2004. Galanin-like peptide but not galanin stimulates sexual behavior in male rats. Hormones and Behavior 46: 551-557.

Irwig, M.S., G.S. Fraley, B.V. *Acohido, S.M. *Popa, M.J. Cunningham, M.J. Gottsch, J.T. Smith, D.K. Clifton, and R.A. Steiner. 2004. Kisspeptin-54 Activates Gonadotropin-Releasing Hormone (GnRH) Neurons in the Rat. Neuroendocrinology. 80: 264-272.

Kauffman, A.S., J. Buenzle, G.S. Fraley, and E.F. Rissman. 2005. Effects of galanin-like peptide (GALP) on locomotion, reproduction, and energy balance in female mice. Hormones and Behavior. 48(2):141-151.

*Stoyanovich, A.G.,1 *Johnson, M.A., Clifton, D.K., Steiner, R.A. and Fraley, G.S. 2005. Galanin-like peptide rescues reproductive function in the diabetic rat. Diabetes. 54: 2471-2476.

Fraley, G.S. 2006. Immunolesions of glucoresponsive projections to the arcuate nucleus alter glucoprivic-induced alterations in food intake, luteinizing hormone secretion, and GALP mRNA but not sex behavior in adult male rats. Neuroendocrinology. In press.

Thomas, P.S. Jr., G.S. Fraley, V.Damien, L.B. Woodke, F. Zapata, B.L. Sopher, S.R. Plymate, and A.R. La Spada. 2006. Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy. Human Molecular Genetics. In press.