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Information for InvestigatorsApplication for Vertebrate Animal Use—Instructions
As you complete this Application, please be aware that copies of completed applications may be released to the public under the Michigan Freedom of Information Act. If there is a request for your application, you will be notified prior to release. If you should receive inquiries from the public concerning your project, please contact the current chairperson of the Hope College Animal Care and Use Committee.
GENERAL INFORMATION AND INSTRUCTIONS
College policy and federal law require a review of projects for humane treatment and judicious and safe use of vertebrate animals. At Hope College, the review is conducted by the Hope College Animal Care and Use Committee (HCACUC).
Principal investigators and course instructors must obtain approval from HCACUC before initiating any research, testing or instructional project involving the use of vertebrate animals. (The U.S. Public Health Service requires verification of HCACUC approval of animal care and use within 60 days after submission of an application or proposal.) HCACUC does not review projects for scientific merit except as the question of merit bears on humane treatment or safe use of the animals. HCACUC's principal areas of concern are housing and husbandry, health status of animals, veterinary medical care, measures to minimize pain or discomfort, and the adequacy of training or experience of the personnel using the animals.
HUMANE USE CATEGORIES
In Item 1 of the following Form, investigators and course instructors are requested to categorize their use of vertebrate animals on the basis of the discomfort or pain involved. HCACUC has designated three categories:
Consideration should be given to methods that result in a lesser degree of unavoidable pain or discomfort, and use of the smallest number of animals consistent with accomplishing the scientific or educational objectives. Examples of procedures in each category are given below.
Category A:Procedures that involve little or no discomfort or pain. Procedures that if carried out in human subjects would not require anesthesia or analgesia, such as subcutaneous or intramuscular injections or withdrawal of blood; behavioral testing that does not involve restraint or exposure to noxious stimuli; studies conducted on completely anesthetized animals which do not regain consciousness; standard methods of euthanasia that result in rapid loss of consciousness and death; studies that do not produce significant abnormal physiological or behavioral states.
Category B: Procedures that may result in some discomfort or pain, but of short duration. Procedures that can be performed humanely under local anesthesia, such as exposure of superficial blood vessels or simple passage of catheters; surgical procedures under general anesthesia that could result in functional deficit or post-operative pain or discomfort that is limited to the immediate post-operative period; physiological or behavioral studies of conscious animals that may involve short-term restraint; food or water deprivation for moderate periods; exposure to noxious stimuli from which escape is possible; short-term social isolation or crowding. Humane concerns in this category relate to the degree and duration of unavoidable pain or discomfort.
Category C: Procedures that may result in significant discomfort or pain. Major surgical procedures under anesthesia that could result in substantial post-operative pain, discomfort, or functional deficit; exposure to noxious stimuli from which escape is impossible; prolonged physical restraint; imposition of significant behavioral stress; prolonged deprivation of food or water.
An application must be approved for all research, testing, or instructional projects. Approved applications are valid for the specified project period or three years, whichever is less. HCACUC approval must be obtained prior to significant changes in approved protocols. Significant changes are those that potentially affect the level of pain or discomfort that the animals might experience.
Normally, HCACUC will review Applications within 30 days of receipt. In conjunction with the start of a project, an approval number will be assigned. No project involving the use of vertebrate animals may be initiated without an approval number. The number must accompany all requisitions for procurement of animals. It also must be obtained for projects where animals are not directly purchased (e.g. wild trapping, donated, in-house breeding, obtained from other laboratories or other noncommercial sources). Only those species that are listed in the approved application may be procured.
HCACUC has available a repository of information on anesthetic, analgesic and tranquilizer agents, laws and standards, and other aspects of the humane care and use of animals. The USPHS Guide for the Care and Use of Laboratory Animals are available from HCACUC on request.
Consultation or assistance on matters related to this application is available from the current chairperson of the HCACUC, to whom the completed application should be submitted.
HOPE COLLEGE PRINCIPLES FOR THE CARE AND USE OF LABORATORY ANIMALS
(Adapted from US Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training)
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