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Picture of Gregory S. Fraley Gregory S. Fraley Associate Professor of Biology

Publications

*Denotes undergraduate students, **Denotes High school students

  • Karcher, D., M. Makagon, S.M. Fraley, G.S. Fraley, M. Lilburn. 2012. Effects of flooring type on wellbeing of Pekin ducks. Poultry Sci. (in press).
  • *Constant JP, Fraley GS, Forbes E, Hallas BH, Leheste JR, Torres G. 2012. Resveratrol protects neurons from cannulae implantation injury: Implications for deep brain stimulation. Neuroscience. Jul 13. (in press).
  • *Mohr MA, *Leathley E, Fraley GS. 2012. Hypothalamic Galanin-like Peptide (GALP) Rescues the Onset of Puberty in Food-Restricted Weanling Rats. J Neuroendocrinol. (in press)
  • Clarke IJ, Smith JT, Henry BA, Oldfield BJ, Stefanidis A, Millar RP, Sari IP, Chng K, Fabre-Nys C, Caraty A, Ang BT, Chan L, Fraley GS. 2012. Gonadotropin Inhibitory Hormone Is a Hypothalamic Peptide That Provides a Molecular Switch between Reproduction and Feeding. Neuroendocrinology. 95(4):305-16.
  • Babu B, *Lee M, *Lee L, *Strobel R, *Brockway O, *Nickols A, Sjoholm R, *Tzou S, Chavda S, Desta D, Fraley GS, *Siegfried A, *Pennington W, *Hartley RM, *Westbrook C, *Mooberry SL, *Kiakos K, *Hartley JA, Lee M. 2011. Acetyl analogs of combretastatin A-4: synthesis and biological studies. Bioorg Med Chem. 19(7): 2359-67.
  • *Lee M, *Brockway O, *Dandavati A, *Tzou S, *Sjoholm R, *Nickols A, Babu B, Chavda S, Satam V, *Hartley RM, *Westbrook C, *Mooberry SL, Fraley GS, Lee M. 2011. Design and synthesis of novel enhanced water soluble Hydroxyethyl analogs of combretastatin A-4. Bioorg Med Chem Lett. 21(7): 2087-91.
  • Lawrence CB, Fraley GS. 2011. Galanin-like peptide: neural regulator of energy homeostasis and reproduction. EXS.;102:263-80. Review. PubMed PMID: 21299074.
  • Lawrence C, Fraley GS. 2011. Galanin-like peptide (GALP) is a hypothalamic regulator of energy homeostasis and reproduction. Front Neuroendocrinol. Jan;32(1): 1-9.
  • *Van Der Kolk N, Madison FN, *Mohr M, Eberhard N, Kofler B, Fraley GS. 2010. Alarin stimulates food intake in male rats and LH secretion in castrated male rats. Neuropeptides. Aug;44(4):333-40.
  • Saldanha CJ, Walters BJ, Fraley GS. 2010. Neurons that co-localize aromatase and kisspeptin-like immunoreactivity may regulate the HPG axis of the Mallard drake (Anas platyrhynchos). Gen Comp Endocrinol. 166(3): 606-13.
  • Fraley GS, Steiner RA, Lent KL, Brenowitz EA. 2010. Seasonal changes in Androgen receptor mRNA in the brain of the white-crowned sparrow. Gen Comp Endocrinol. 166(1): 66-71.
  • *Taylor A, Madison FN, Fraley GS. 2009. Galanin-like peptide stimulates feeding and sexual behavior via dopaminergic fibers within the medial preoptic area of adult male rats. J Chem Neuroanat. 37(2): 105-11.
  • Dungan Lemko HM, Clifton DK, Steiner RA, Fraley GS. 2008. Altered response to metabolic challenges in mice with genetically targeted deletions of galanin like peptide. Am J Physiol Endocrinol Metab. 295(3): E605-12.
  • *Johnson MA, Fraley GS. Rat RFRP-3 alters hypothalamic GHRH expression and growth hormone secretion but does not affect KiSS-1 gene expression or the onset of puberty in male rats. Neuroendocrinology. 2008;88(4): 305-15.
  • *Rich N, Reyes P, **Reap L, **Goswami R, Fraley GS. 2007. Sex differences in the effect of prepubertal GALP infusion on growth, metabolism and LH secretion. Physiol Behav. Dec 5;92(5):814-23.
  • Todd BJ, Fraley GS, Peck AC, Schwartz GJ, Etgen AM. 2007. Central insulin like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats. Biol Reprod. Sep;77(3):492-503.
  • *Johnson MA, Tsutsui K, Fraley GS. 2007. Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat. Horm Behav. Jan;51(1):171-80.
  • Fraley GS. 2006. Immunolesions of glucoresponsive projections to the arcuate nucleus alter glucoprivic-induced alterations in food intake, luteinizing hormone secretion, and GALP mRNA, but not sex behavior in adult male rats. Neuroendocrinology. 83(2): 97-105.
  • Thomas PS Jr, Fraley GS, Damian V, Woodke LB, Zapata F, Sopher BL, Plymate SR, La Spada AR. 2006. Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy. Hum Mol Genet. 15(14): 2225-38.
  • *Stoyanovitch AG, *Johnson MA, Clifton DK, Steiner RA, Fraley GS. 2005. Galanin-like peptide rescues reproductive function in the diabetic rat. Diabetes. 54(8): 2471-6.
  • Kauffman AS, Buenzle J, Fraley GS, Rissman EF. 2005. Effects of galanin-like peptide (GALP) on locomotion, reproduction, and body weight in female and male mice. Horm Behav. 48(2): 141-51.
  • Irwig MS, Fraley GS, Smith JT, Acohido BV, Popa SM, Cunningham MJ, Gottsch ML, Clifton DK, Steiner RA. 2004. Kisspeptin activation of Gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology. 80(4): 264-72.
  • Fraley GS, **Thomas-Smith SE, *Acohido BV, Steiner RA, Clifton DK. 2004. Stimulation of sexual behavior in the male rat by galanin-like peptide. Horm Behav. 46(5): 551-7.
  • Fraley GS, *Scarlett JM, Shimada I, *Teklemichael DN, *Acohido BV, Clifton DK, Steiner RA. 2004. Effects of diabetes and insulin on the expression of galanin like peptide in the hypothalamus of the rat. Diabetes. 53(5): 1237-42.
  • Hansen KR, Krasnow SM, *Nolan MA, Fraley GS, *Baumgartner JW, Clifton DK, Steiner RA. 2003. Activation of the sympathetic nervous system by galanin like peptide--a possible link between leptin and metabolism. Endocrinology. 144(11): 4709-17.
  • Fraley GS, Shimada I, *Baumgartner JW, Clifton DK, Steiner RA. 2003. Differential patterns of Fos induction in the hypothalamus of the rat following central injections of galanin-like peptide and galanin. Endocrinology. 144(4): 1143-6.
  • Krasnow SM, Fraley GS, *Schuh SM, *Baumgartner JW, Clifton DK, Steiner RA. 2003. A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouse. Endocrinology. 144(3): 813-22.
  • Fraley GS, Ritter S. 2003. Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus. Endocrinology. 144(1): 75-83.
  • Fraley GS, Ulibarri CM. 2002. Long-term castration effects motoneuron size but not number in the spinal nucleus of the bulbocavernosus in the adult male Mongolian gerbil. Brain Res. 953(1-2): 265-71.
  • Fraley GS, Ulibarri C. 2002. Development of androgen receptor and p75(NTR) mRNAs and peptides in the lumbar spinal cord of the gerbil. Brain Res Dev Brain Res.137(2): 101-14.
  • Fraley GS, Dinh TT, Ritter S. 2002. Immunotoxic catecholamine lesions attenuate 2DG-induced increase of AGRP mRNA. Peptides. Jun;23(6):1093-9.
  • Fraley GS. 2002. Immunolesion of hindbrain catecholaminergic projections to the medial hypothalamus attenuates penile reflexive erections and alters hypothalamic peptide mRNA. J Neuroendocrinol. 14(5): 345-8.
  • Horowitz JM, Vernace VA, Myers J, Stachowiak MK, Hanlon DW, Fraley GS, Torres G. 2001. Immunodetection of Parkin protein in vertebrate and invertebrate brains: a comparative study using specific antibodies. J Chem Neuroanat. 21(1): 75-93.
  • Fraley GS, Ulibarri C. 2001. Sexual dimorphism in the number and size of SNB motoneurons: delayed development during normal ontogeny. Brain Res Dev Brain Res.126(1): 57-64.
  • Fraley GS, Kuenzel WJ. 1993. Immunocytochemical and histochemical analyses of gonadotrophin releasing hormone, tyrosine hydroxylase, and cytochrome oxidase reactivity within the hypothalamus of chicks showing early sexual maturation. Histochemistry. 99(3): 221-9.
  • Fraley GS, Kuenzel WJ. 1993. Precocious puberty in chicks (Gallus domesticus) induced by central injections of neuropeptide Y. Life Sci. 52(20): 1649-56.
  • Invited Reviews and Book Chapters

  • Lawrence C, Fraley GS. 2011. Galanin-like peptide (GALP) is a hypothalamic regulator of energy homeostasis and reproduction. Front Neuroendocrinol. 102:263-80.
  • Lawrence C, Fraley GS. 2011. Galanin-like Peptide (GALP): Neural Regulator of Energy Homeostasis and Reproduction. In: Galanin. Experimenta Supplementum, Vol. 102. Ed. Hokfelt, T. Springer Verlag Berlin Heidelberg.
  • Honors and Awards

  • 1988 Macintosh Corporation Award for Computer Aided Instruction: Educational Computer Programming Conference (EduCom 1988)
  • 1990 Sigma Xi Graduate Student Paper Competition: Awarded Membership
  • 1991 C.S. Schaffner Award
  • 1992 East Coast Hatchery Association Award for Research Excellence
  • 1993 Sigma Xi Grant-in-Aid Research
  • 1993-95 Poncin Research Foundation Scholarship
  • 1994 Sigma Xi Grant-in-Aid of Research
  • 1995-96 Washington State University Graduate School Travel Award
  • 1998 Veterinary Gross Anatomy Teaching Award
  • 2000-2002 Poncin Research Foundation Postdoctoral Fellowship Award
  • 2003 Travel Award, Society for Behavioral Neuroendocrinology
  • 2006-2012 Member, Organization Committee for West MI Regional Undergraduate Scientific Research Symposium
  • 2008-2010 Awards Committee Member, Society for Behavioral Neuroendocrinology
  • 2012 Elected Member, National Advisory Board for the American Pre-Veterinary Medical Association
  • 2012 "Teller" for Poultry Science Association Annual Business Meeting
  • Invited Presentations

  • 2005 University of Queratero, Queratero, Mexico. "The brain as an integrator of nutrition and reproduction: implications for diabetes and anorexia."
  • 2006 LeHigh University invited seminar "Food, Fat, Sex & Diabetes: How the Brain Mediates Metabolism and Reproduction."
  • 2006 Keystone Symposium Gut Hormones and Other Regulators of Appetite, Satiety and Energy Expenditure, Mar 2 - 7, 2006, Santa Fe, New Mexico.
  • 2006 Endocrine Society Annual Meeting Plenary session, Endocrine Determinants of Sexual Behavior invited talk, "The Effects of Galanin-like Peptide (GALP) on Sexual Behavior in the Male."
  • 2006 Han-Mo Koo Memorial Seminar Series Van Andel Research Institute. "Food, Fat, Sex & Diabetes: How the Brain Mediates Metabolism and Reproduction."
  • 2007 Metabolic Control of Reproduction, invited seminar, New York Institute of Technology, New York College of Medicine (NYCOM)
  • 2008 Brain, Fat and Sex: Neural Mechanisms that Integrate Nutrition and Reproductive Function. Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Austria
  • 2009 Mammalian RFRP-3: "Regulator of GnRH or Feeding Systems?" Winter Conference on Brain Research, Copper Mountain, CO.
  • 2009 *Van Der Kolk, N., F.N. Madison, M. Mohr*, N. Eberhard, B. Kofler, and G.S.Fraley. 2009. Alarin is a neuromediator of energy metabolism. European Neuropeptides Meeting, Salzburg, Austria.
  • 2010 Environmental Impacts on the Neural Regulation of Reproduction in the Pekin duck. Maple Leaf Farms, Inc. Annual Duck Research Symposium. Warsaw, IN.
  • 2011 Brain, Fat and Sex: Neural Mechanisms that Integrate Nutrition and Reproductive Function. Biology Dept. Andrews University, South Haven, MI.
  • 2011 Environmental Impacts on the Neural Regulation of Reproduction in the Pekin duck. New York College of Osteopathic Medicine, Long Island, NY.
  • 2011 Environmental Impacts on the Neural Regulation of Reproduction in the Pekin duck. Maple Leaf Farms, Inc. Annual Duck Research Symposium. Warsaw, IN.
  • 2011 Deep Brain Stimulation: Key Safety Issues. "Non-pharmocological approaches for the treatment of Parkinson's disease." Satellite Meeting, Society for Neuroscience Annual Meeting, Washington. D.C.
  • 2012 Descriptive analyses of the development of gait in Pekin ducks from hatch to market weight. Maple Leaf Farms, Inc. Annual Duck Research Symposium.
  • Patents

    *Denotes undergraduate students, **Denotes High school students

  • 2007. Lowry, D., D. O'Farrell, S. Tuinstra, R. Veldman, D. Daugherty, G.S. Fraley, *K. Harrison, and *M. Johnson. "Vertebrally Mounted Tissue Retractor and Method for Use in Spinal Surgery." U.S. Patent No. 60/976,331.
  • Competitive Funds Acquired

  • 1991 C.S. Schaffner Award
  • 1993 Sigma Xi Grant-in-Aid Research
  • 1993-95 Poncin Research Foundation Scholarship
  • 1994 Sigma Xi Grant-in-Aid of Research
  • 1995-96 Washington State University Graduate School Travel Award
  • 1998-99 UCLA Brain Research Institute, Laboratory for Neuroendocrinology Postdoctoral Research Fellowship Institutional Award
  • 2000-2002 Poncin Research Foundation Postdoctoral Fellowship
  • 2003 NIDDK K01Career Advancement Award, Metabolic Control of Reproduction (DK066238-01A1)
  • 2006 NSF, MRI Award (CO- PI), MRI: Acquisition of Apotome/Fluorescence Microscope Imaging System for Enhanced Research in the Biological Sciences at Hope College
  • 2007 HHMI Award for Development of Neuroscience Capstone Course.
  • 2007 CO-PI: Supplement to MRI: Acquisition of Apotome/Fluorescence Microscope Imaging System for Enhanced Research in the Biological Sciences at Hope College
  • 2008 HHMI Faculty Development Grant: Rehearsal vs. Performance: Salivary Cortisol Levels as a Physiological Response in Dancers
  • 2008 CO-PI: NSF REU site, Environmental Impacts on Biological Systems: From Molecules to Ecosystems.
  • 2010 PI: A New Focus in Research: Investigating the Neurobiology of and Treatments for Neurodegenerative Disease. Great Lakes College Association
  • 2010 PI: Identification of neutraceuticals for reducing traumatic brain injury. HHMI grant.
  • 2011-2013 PI: Resveratrol Reduces Cell Injury Caused by Surgery Mimicking Deep Brain Stimulation. Campbell Foundation grant.
  • 2011 PI: Analyses of Gait in Commercial Strains of Pekin Ducks. Great Lakes Association New Directions Initiative.
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Contact Details

Phone: 616-395-7306
Fax: 616-395-7125
Email: fraley@hope.edu
Office: Science Center 3065
Lab: Science Center 3011

Office Hours

Please make an appointment to see me.