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Book Edited     Presentations     Invited Talks

Books Edited
  1. M. Lee, Ed. In Topics of Heterocyclic Chemistry: Heterocyclic Antitumor, Antbiotics. Springer, Berlin, 2006.

  2. M Lee and L. Strekowski, Eds. In Synthetic and Biophysical Studies of DNA binding Compounds. Transworld Research Network, Trivandrum - 695023, Kerala, India, 2007.

Publications

76. K.N. Kirschner, M. Lee, R.C. Stanley and J.P. Bowen, 2000, Density Function and Ab Initio Studies on N-Acetyl-Duocarmycin SA: Insight into its DNA interaction Properties, Bioorg. Med. Chem. 8, 329-335.

77. N. Brooks, P.J. McHugh, M. Lee and J.A. Hartley, 2000, Alteration in the Choice of DNA Repair Pathway with Increasing Sequence Selective DNA Alkylation in the Minor Groove, Chem. Biol. 7, 659-668.

78. S.A. Jennings, T.T. Howard, S.G. Roller, N. Brooks, C. O’Hare, K. Kiakos, J.A. Hartley, P.J. Burke, and M. Lee, 2001, Efficient Synthesis of (±)-seco-Cyclopropaneindoline Analogs of CC-1065, Heterocyclic Commun. 7, 7-16.

79. E.R. Lacy, N.M. Le, C.A. Price, M. Lee and W.D. Wilson, 2002, Influence of an N-Terminal Formamido Group on the Sequence Recognition of DNA by Polyamides, J. Am. Chem. Soc. 124, 2153-2163.

80. E.R. Lacy, K.K. Cox, W.D. Wilson and M. Lee, 2002, Recognition of T.G Mismatched Base Pairs in DNA by Stacked Imidazole-Containing Polyamides: Surface Plasmon Resonance and Circular Dichroism Studies, Nucl. Acids Res. 30, 1834-1841.

81. K. Kiakos, T.T. Howard, M. Lee, J.A. Hartley and P.J. McHugh, 2002, Saccharomyces cerevisiae Rad5 Influences the Excision Repair of Some DNA Minor Groove Adducts, J. Biol. Chem. 277, 44576-44581.

82. J.L. Toth, C.A. Price, E. C. Madsen, H.L. Handl, S.J. Hudson, R.B. Hubbard III, J.P. Bowen, K. Kiakos, J.A. Hartley and M. Lee, 2002, Sequence Selective Recognition of DNA by Hairpin Conjugates of Racemic seco-Cyclopropaneindoline-2-benzofurancarboxamido and Polyamides, Bioorg. Med. Chem. Lett. 12, 2245-2248.

83. T.T. Howard, B.M. Lingerfelt, B.L. Purnell, A.E. Scott, C.A. Price, H.M. Townes, L.McNulty, H.L. Handl, K. Summerville, S.J. Hudson, P.J. Bowen, K. Kiakos, J.A. Hartley and M. Lee, 2002, Novel Furano Analogs of Duocarmycin C1 and C2: Design, Synthesis and Biological Evaluation of seco-iso-Cyclopropylfurano[e]indoline (seco-iso-CFI) and the Unexpected seco-Cyclopropyltetrahydrofurano[f]quinoline (seco-CFQ) Analogs, Bioorg. Med. Chem. 10, 2941-2952.
84. H. Townes, K. Summerville, B. Purnell, M. Hooker, E. Madsen, S. Hudson and M. Lee, 2002, Investigation of Novel Analogs of a Reductively-Activated Anticancer Prodrug of seco-CBI-TMI, An Analog of Duocarmycin SA, Med. Chem. Res. 11, 248-253.
85. E.R. Lacy, E.C. Madsen, M. Lee and W.D. Wilson, 2003, Polyamide Dimer Stacking in the Minor Groove and Recognition of T.G Mismatched Base Pairs of DNA. In Small Molecule DNA and RNA Binders: From Synthesis to Nucleic Acid Complexes, Vol. 2, M. Demeunynck, C. Bailly and W.D. Wilson Eds., Wiley-VCH, New York. p. 384-413.

86. C. Howard, A. Collins and M. Lee, 2002, Synthesis and Photosensitization Properties of 1,5-Di(netropsin)- and 1,5-Di(lexitropsin)anthraquinone Conjugates, Proc. of the 16th Nat. Conf. on Undergraduate Res. 1-7.

87. A. M. DiFrancesco, S. P. Mayalarp, S. Kim, J. Butler, and M. Lee, 2003, Synthesis and Biological Evaluation of Novel Diaziridinylquinone-acridine Conjugates, Anti-Cancer Drugs 14, 601-615.

88. R. Ayyad, H. Pati, R. Khan, and M. Lee, 2003, Design, Synthesis and Biological Evaluation of a Novel DZQ-Polyamide Conjugate, Heterocyclic Commun. 9, 331-334.

89. J. Toth, J. Henry, Z. Taherbhai, A. Staples, K. Summerville, H. Handl, K. Kiakos, J. Hartley, and M. Lee, 2003, Cytotoxicity and Sequence Specificity of C- and N-terminus Conjugates of N-Methylpyrrole Polyamides with seco-Cyclopropaneindoline, Med. Chem. Res. 12, 87-93.

90. H. Pati, P. Weisbruch, A. Lemon, and M. Lee, 2004, Synthesis of N-Benzylated Anilines from Reactions of Anilines with Benzyl Chloroformate, Syn. Commun. 34, 933-940.

91. H. Pati, R. LeBlanc, and M. Lee, 2003, An Efficient Method for the Synthesis of Substituted 4-Acetoxynaphthalene-2-carboxylate Esters, Ethyl 4-acetoxybenzofuran-6-carboxylate, and Ethyl 4-acetoxybenzothiophene-6-carboxylate, Heterocyclic Commun. 9, 587 - 592.

92. E.R. Lacy, B. Nguyen, M. Le, K.K. Cox, M. Lee, C. O’Hare, J.A. Hartley, and W.D. Wilson, 2004, Energetic Basis for Selective Recognition of the T•G Mismatched Base Pairs in DNA by Imidazole-rich Polyamides, Nucl. Acids Res. 32, 2000-2007.

93. H. Pati, L. Forrest, H., Townes, B., Lingerfelt, B. L., McNulty, and M. Lee, 2004, An Unexpected Synthesis of seco-Cyclopropyltetrahydroquinoline From a Radical 5-Exo-Trig Cyclization Reaction: Analogs of CC-1065 and the Duocarmycins, Molecules 9, 125-133.

94. J. Henry, M. Le, B. Nguyen, C. Howard, S. Bailey, S. Horick, K. Buchmueller, M. Kocheta, D. Hochhauser, J. A. Hartley, W.D. Wilson, and M. Lee, 2004, Targeting the Inverted CCAAT Box 2 by JH-37, an Imidazole-Pyrrole Polyamide Hairpin: Design, Synthesis, Molecular Biology and Biophysical Studies, Biochemistry 43, 12249-12257.

95. H. Pati, Z. Taherbhai, L.Forrest, M. Wicks, S. Bailey, A. Staples, M. Stewart, W. Pennington, J. Harris and M. Lee, 2004, A Stereospecific Route for the Preparation of Trans-Combretastatin Analogs: Synthesis and Cytotoxicity, Lett. Drug Design & Discovery 1, 275-278.

96. J.L. Toth, J. D. Trzupek, L. V. Flores, K. Kiakos, J. A. Hartley, W. T. Pennington, and M. Lee, 2005, A Novel Achiral seco-Amino-Cyclopropylindoline (CI) Analog of CC-1065 and the Duocarmycins: Design, Synthesis and Biological Studies, Medicinal Chemistry 1, 13-19.

97. S. Kupchinsky, S. Centioni, T. Howard, J. Trzupek, S. Roller, V. Carnahan, H. Townes, B. Purnell, C. Price, H. Handl, K. Summerville, K. Johnson, J. Toth, S. Hudson, K. Kiakos, J. A. Hartley, and M. Lee, 2004, Novel Class of Achiral seco-Analogs of CC-1065 and the Duocarmycins: Design, Synthesis, DNA Binding, and Anticancer Properties, Bioorg. Med. Chem. 12, 6221-6236.

98. K. L. Buchmueller, A. M. Staples, C. M. Howard, S. M. Horick, P. B. Uthe, N. M. Le, K. K. Cox, B. Nguyen, K. A.O. Pacheco, W. D. Wilson, and M Lee. 2005, Extending the Language of DNA Molecular Recognition by Polyamides: Unexpected Influence of Imidazole and Pyrrole Arrangement on Binding Affinity and Specificity, J. Am. Chem. Soc. 127, 742-750.

99. K. L. Buchmueller, S. M. Horick, C. M. Howard, P. B. Uthe, A. M. Staples, S. Bailey, N. M. Le, K. K. Cox, J. Henry, W. D. Wilson, and M. Lee. 2005, Competitive Dialysis of Polyamides with Short DNA Hairpins, Letters in Drug Design & Discovery 2, 137-142.

100. H.N. Pati, H. L. Holt, Jr., R. LeBlanc, J. Dickson, M. Stewart, T. Brown, and M. Lee. 2005, Synthesis and Cytotoxic Properties of Nitro- and Aminochalcones, Med. Chem. Res. 14, 19-25.

101. K. Daniell, M. Stewart, E. Madsen, M. Le, H. Handl, N. Brooks, K. Kiakos, J. A. Hartley, and M. Lee, 2005, Design, Synthesis and Biological Evaluation of Achiral Analogs of Duocarmycin SA, Bioorg. Med. Chem. Lett. 15, 177-180.

102. K.L. Buchmueller, A.M. Staples, P.B. Uthe, C.M. Howard, K.A.O. Pacheco, K.K. Cox, J. Henry, S. Bailey, S.M. Horick, B. Nguyen, W.D. Wilson, and M. Lee, 2005, Molecular Recognition of DNA Base Pairs by the Formamido/Pyrrole and Formamido/Imidazole Pairings in Stacked Polyamides, Nucl. Acids Res. 33, 912-921.

103. H.N. Pati, M. Wicks, H.L. Holt, R. Leblanc, P. Weisbruch, L. Forrest, and M. Lee, 2005, Synthesis and Biological Evaluation of cis-Combretastatin Analogs and their Novel 1,2,3-Triazole Derivatives, Heterocyclic Commun. 11, 117-120.

104. P.B. Uthe, A.M. Staples, M. Turlington, J. Jones, K. Blackmon, S. Bailey, K. Buchmueller, and M. Lee, 2005, Novel Picolinic Acid-containing Pyrrole-Imidazole Polyamides: Synthesis and T•G Mismatched Base Pair Recognition, Heterocyclic Commun. 11, 163-166.

105. J. Dickson, L. Flores, M. Stewart, H. L. Holt, Jr., Regan LeBlanc, and M. Lee, 2006, Synthesis and Cytotoxic Properties of Chalcones: An Interactive and investigative Undergraduate Laboratory Project at the Interface of Chemistry and Biology, J. Chem. Ed. 83, 934-936.

109. A. Sato, L. McNulty, K. Cox, S. Kim, A. Scott, K. Daniell, K. Summerville, C. Price, S. Hudson, K. Kiakos, J. A. Hartley, T. Asao, and M. Lee. 2005. A Novel Class of In-vivo Active Anticancer Agents: Achiral Seco-Amino and Seco-Hydroxycyclopropylbenz[e]indolone (seco-CBI) Analogs of the Duocarmycins and CC-1065, J. Med. Chem. 48, 3903-3918.

110. C. A. Price, B. M. Lingerfelt, H. L. Handl, K. Kiakos, J. A. Hartley, and M. Lee. 2005. Sequence Specific Recognition of DNA by Tailor Made Hairpin Conjugates of Achiral seco-Cyclopropaneindoline-2-benzofurancarboxamide and Pyrrole-Imidazole Polyamides, Bioorg. Med. Chem. Lett. 15, 3151-3156.

111. R. LeBlanc, J. Dickson, T. Brown, M. Stewart, H. N. Pati, D. VanDerveer, H. Arman, J. Harris, W. T. Pennington, H. L. Holt, Jr., and M. Lee. 2005. Synthesis and Cytotoxicity of Epoxide and Pyrazole Analogs of Combretastatin. Bioorg. Med. Chem. 13, 6025-6034.

112. H. L. Holt, Jr., R. LeBlanc, J. Dickson, T. Brown, J. R. Maddox, and M. Lee. 2005. Unexpected Retro-Aldol Condensation of Chalcones: A Structure and Reactivity Study. Heterocyclic Commun. 11, 465-470.

113. K. L. Buchmueller, Z. Taherbhai, C. M. Howard, S. L. Bailey, B. Nguyen, D. Wilson, C. O’Hare, D. Hochhauser, J. A. Hartley, and M. Lee. 2005. Design of a Hairpin Polyamide, ZT65B, for Targeting the Inverted CCAAT Box (ICB) Site in the Multidrug Resistant (MDR1) Gene. ChemBiochem. 6, 2305-2311.

114. B. Purnell, B. Lingerfelt, A. Scott, H.Townes, K. Summerville, S. Hudson, K. Kiakos, J. Hartley and M. Lee, 2006, Novel (S)-(+)- and (R)-(-)-seco-iso-CFI Analogs of Duocarmycin C2. Medicinal Chemistry 2, 139-146.

115. M. Turlington, H. Mackay, C. Rutledge, Z. Taherbhai, B. Nguyen, W. D. Wilson and M. Lee, 2006, Synthesis and DNA Binding Properties of a Benzamidine-containing Polyamide Analog. Heterocyclic Commun. 12, 89-92.

116. T. Brown, H. L. Holt, Jr. and M. Lee, 2006, Novel Heterocyclic Analogs of Combretastatins. In Topics of Heterocyclic Chemistry: Heterocyclic Antitumor, Antbiotics. M. Lee Ed., Springer Verlag, Berlin, pp 1-52.

117. L. V. Flores, Jr., A. M. Staples, H. Mackay, C. M. Howard, P. B. Uthe, J. S. Sexton, III, K. L. Buchmueller, W.D. Wilson, C. O’hare, J. Kluza, D. Hochhauser, J. A. Hartley and M. Lee. 2006. Synthesis and Evaluation of an Intercalator-Polyamide Hairpin Designed to Target the Inverted CCAAT Box 2 in the Topoisomerase II? Promoter. ChemBiochem. 7, 1722-1729.

118. A. Sato, A. Scott, S. Kim, T. Asao and M. Lee, 2006, An Efficient Synthesis of an Achiral seco-cyclopropylhydroxybenz[2,3-e]indoline (CBI) Analog: Achiral seco-CBI-TMI. J. Org. Chem. 71, 4692-4695.

119. T. Brown, Z. Taherbhai, J. Sexton, A. Sutterfield, M. Turlington, J. Jones, L. Stollings, M. Stewart, K. Buchmueller, H. Mackay, C. O'Hare, J. Kluza, B. Nguyen, David Wilson, M. Lee and J. A. Hartley, 2007, Synthesis and Biophysical Evaluation of Minor-groove Binding C-Terminus Modified Pyrrole and Imidazole Triamide Analogs of Distamycin. Bioorg. Med. Chem. 15, 474-483.

120. K.L. Buchmueller, S.L. Bailey, D.A. Matthews, Z.T. Taherbhai, T. Brown, J. Register, Z.S. Davis, C.D. Bruce, B. Nguyen, W.D. Wilson, C. O’Hare, J.A. Hartley, and M. Lee, 2006, Physical and Structural Basis for the Strong Interactions of the –ImPy– Central Pairing Motif in the Polyamide, f-Im-Py-Im. Biochemistry 45, 13551-13565.

121. H. Mackay, T. Brown, and M. Lee. 2007, Recent Developments of Minor Groove Binding Polyamide Analogs of Distamycin: A Review on Structural Modifications and Establishment of a Language of Sequence Specific DNA Recognition. In Synthetic and Biophysical Studies of DNA binding Compounds. Transworld Research Network, Trivandrum - 695023, Kerala, India, p67-92.

122 P.J. Bowen, Haizhen, and M. Lee, 2007, Computational Studies of Small Molecular DNA Interactions. In Synthetic and Biophysical Studies of DNA binding Compounds. Transworld Research Network, Trivandrum - 695023, Kerala, India, p93-130.

123. B. Purnell, A. Sato, A. O’Kelley, C. Price, K. Summerville, S. Hudson, C. O’Hare, K. Kiakos, J. A. Hartley, T. Asao and M. Lee, 2006, DNA Interstrand Crosslinking Agents: Synthesis, DNA Interactions, and Cytotoxicity of Dimeric Achiral seco-amino-CBI and Conjugates of Achiral seco-Amino-CBI with Pyrrolobenzodiazepine (PBD). Bioorg. Med. Chem. Lett. 16, 5677-5681.

124. D. Hochhauser, M. Kotecha, C. O’Hare, B. Friedmann, R. Mantovani, M. Lee and John A. Hartley, 2007, Modulation of Topoisomerase II? Expression in Mammalian Cells with a Sequence-Specific Polyamide. Molecular Cancer Therapeutics 6, 346-354.

125. D. Harris, M. Stewart, K. Mulder, A. Sielaff, T. Brown, H. Mackay and M. Lee, 2007, Solution Phase Synthesis of Imidazole/Pyrrole-Containing Hairpin Polyamides. Heterocyclic Commun. 13, 17-23.

126. T. Bultman and M. Lee, “The Role of Academic Administration in Achieving Academic Excellence.” In Developing and Sustaining a Research-Supportive Curriculum: A Compendium of Successful Practices, K. K. Karukstis and T. E. Elgren, Eds., Council on Undergraduate Research, Washington, D.C., 2007, pp. 105-107.

127. N. M. Le, A. Sielaff, A. Cooper, M. Le, H. Mackay, T. Brown, M. Kocheta, C. O’Hare, D. Hochhauser, M. Lee and J. Hartley, 2006, Molecular Recognition of f-PIP, a Pyrrole- and Imidazole-triamide to the Inverted CCAAT Box-2 Site of the Topoisomerase II? Promoter and Modulation of Gene Expression in Cells. Bioorg. Med. Chem. Lett. 16, 6161-6164.

128. J. Ruprich, A. Proudt, P. Nolan, B. Younglove, J. Dickson, R. LeBlanc, H. Holt, Jr., P. Hills, T. Brown, H. Mackay, S.L. Mooberry and M. Lee, 2007, Design, Synthesis, and Biological Testing of Cyclohexenone Derivatives of the Combretastatins. Letters in Drug Design & Discovery 4, 144-148.

129. K. Mulder, J. Jones, M. Lee and T. Brown, 2008, Synthesis of N-Formamido Pyrrole- and Imidazole Acids. Synth. Commun. 38, 33-44.

130. C. C. O’Hare, P. Uthe, H. Mackay, K. Blackmon, J. Jones, T. Brown, B. Nguyen, W. D. Wilson, M. Lee and J. A. Hartley, 2007, Sequence recognition in the minor groove of DNA by Covalently Linked Formamido-Imidazole-Pyrrole-Imidazole Polyamides: The Effect of H-pin Linkage and Linker Length on Selectivity and Affinity, Biochemistry 46, 11661-11670.

131. S. K. Yanow, L. A. Purcell, A. Sato, M. Lee and T. Spithill, 2008, A Novel DNA Binding Agent Exhibits Potent Anti-malarial Activity in-vivo, J. Infect. Dis. 197, 527-534.

132. S. K. Yanow, L. A. Purcell, M. Lee, and T.W. Spithill, 2007, Genomics-based Drug Design Targets the AT-rich Malaria Parasite, Pharmacogenomics 8, 1267-1272.

133. M. Johnson, B. Younglove, L. Lee, R. LeBlanc, H. Holt, Jr., P. Hills, H. Mackay, T. Brown, S. Mooberry and M. Lee, 2007, Design, Synthesis, and Biological Testing of Pyrazoline Derivatives of Combretastatin-A4. Bioorg. Med. Chem. Lett. 17, 5897-5901.

134. K. Kiakos, A. Sato, T. Asao, P. J. McHugh, M. Lee and J. A. Hartley, 2007,
Characterisation of the DNA Sequence Selective Adenine Alkylation, Mechanisms of Adduct Repair and in vivo Antitumour Activity of the Novel Achiral Seco-amino-CBI Analogue of Duocarmycin AS-I-145, Molecular Cancer Therapeutics 6, 2708-2718.

135. H. Mackay, T. Brown, J. S. Sexton, M. Kotecha, B. Nguyen, W. D. Wilson, J. Kluza, C. O’Hare, D. Hochhauser, J. A. Hartley and M. Lee, 2008, Targeting the Inverted CCAAT Box-2 of the Topoisomerase II? Gene: DNA Sequence Selective Recognition by a Polyamide-Intercalator as a Staggered Dimer, Bioorg. Med. Chem. 16, 2093-2102.

136. H. Zhong, K. N. Kirschner, M. Lee and J. P. Bowen, 2008, Binding Free Energy Calculation for Duocarmycin/DNA Complex Based on the QPLD-Derived Partial Charge Model, Bioorg. Med. Chem. Lett. 18, 542-545.
137. L. A. Purcell, S. K. Yanow, M. Lee, T. W. Spithill and A. Rodriguez, 2008, Chemical Attenuation of Plasmodium berghei Sporozoites Induces Sterile Immunity in Mice, Infect. Immun. 76, 1193-1199.

138. L. Lee, R. Davis, J. Vanderham, P. Hills, H. Mackay, T. Brown, S. L. Mooberry and M. Lee, 2008, 1,2,3,4-Tetrahydro-2-Thioxopyrimidine Analogs of Combretastatin-A4, Eur. J. Med. Chem. In press.

139. T. Brown, H. Mackay, M. Turlington, A. Sutterfield, T. Smith, A. Sielaff, L. Westrate, C. Bruce, C. O'Hare, J. A. Hartley, B. Nguyen, W. D. Wilson and M. Lee, 2008, Modifying the N-Terminus of Polyamides: PyImPyIm has Improved Sequence Specificity over f-ImPyIm. Bioorg. Med. Chem. 16, 5266-5276.

140. K. Mulder, T. Brown, P. Nolan, T.Smith and M. Lee, 2008, Polyamides containing C-terminus ?-alanine-carboxylic acids as intermediates for divergent synthesis, Heterocyclic Commun. 14, 137-139.

141. K. Dittenhafer, U. Das, B. L. Younglove, H. Mackay, T. Brown, J. R. Dimmock, M. Lee and H. Pati, 2008, 2-(3-Arylacryloyl)-3-methylquinoxaline 1,4-dioxides. As potential hypoxic selective cytotoxins, Heterocyclic Commun. 14, 383-386.

142. H. Mackay, T. Brown, P. B. Uthe, L. Westrate, A. Sielaff, J. P. Lajiness, J. Kluza, C. O’Hare, B. Nguyen, C. Bruce, W. D. Wilson, J. A. Hartley and M. Lee, 2008, Sequence Specific and High Affinity Recognition of 5’-ACGCGT-3’ by a Rationally Designed Pyrrole-Imidazole H-pin Polyamide. Bioorg. Med. Chem. Submitted.

143. A. Sielaff, H. Mackay, T. Brown and M. Lee, 2008, The Use of 2-Aminopurine-Cytosine Containing Oligonucleotides and Fluorescence Spectroscopy to Investigate DNA-Polyamide Binding. Biophys. Biochem. Res. Commun. 369, 630-634.

144. R. Davis, D. Umashankar,H. Mackay, T. Brown, S. Mooberry, J. Dimmock, M. Lee and H. Pati, 2008, Synthesis of Curcumin Analogs and Evaluation of their Biological Activity Against Murine Cancer Cell Lines. Archiv der Pharmaczie 341, 440-445.

145. J. Lajiness, A. Sielaff, H. Mackay, T. Brown, B. Nguyen, W.D. Wilson, M. Lee and J.A. Hartley, 2008, Investigating the Importance of Polyamide Curvature in the DNA-Polyamide Binding Motif, Medicinal Chemistry In press.

146. K. Nordell Pearson, K. Brown, H.L. Dershem, K. Winnett-Murray, C.C. Barney and M. Lee, A Comprehensive Approach to Broadening Participation through Research Experiences at Hope College, in Broadening Participation in Undergraduate Research, Council on Undergraduate Research, Washington, D.C., 2008. In press.

147. L.A. Purcell, K.A. Wong, S.K. Yanow, M. Lee, T.W. Spithill and A. Rodriguez, 2008, Chemically attenuated sporozoites are cross-protective and induce specific antibodies and CD8+ T cells, Vaccine 26, 4880-4884.

148. L. Westrate, J.A. Sutterfield, R. Leblanc, T. Brown, Jerome Kluza, J. A. Hartley, B. Nguyen, D. Wilson and M. Lee, 2009, Investigating the Effects of the N-Formamido Moiety on the Binding of Pyrrole- and Imidazole-Containing Triamides with their Cognate 5’-ACGCGT-3’ Sequence, Biochemistry 48, 5679–5688.

149. C. Sameer, R. Davis, A. Ferguson, C. Riddering, K. Dittenhafer, H. Mackay, B. Babu, M. Lee, A. Siegfried, W. Pennington, M. Shadfan, S. L. Mooberry, B. K. Mishra, and H. N. Pati, 2009, Anticancer Testing of a,ß-Unsaturated Ketones as Analogs of Combretastatin-A4, Lett. Drug Design Discovery. 6, 531-537.

150. L. Forrest, B. Babu, S. Chavda and M. Lee, 2010, Design, Synthesis and Cytotoxic Properties of 2-Amino-1-phenylethanol Derivatives, Med. Chem. Res. In Press. DOI: 10.1007/s00044-009-9258-9

151. N. Abraham, B. A. Cunningham, S. Decatur, P. Dehn, M. Lee, and J. M. Osborn, “Supporting Potentially Transformative Research: The Administrator’s Perspective. In Transformative Research At Undergraduate Institutions, Council on Undergraduate Research, Washington, D.C., 2010, pp. 71 - 88.

152. D. Desta, R. Sjoholm, L. Lee, M. Lee, K. Dittenhafer, S. Canche, B. Babu, S. Chavda, C. Dewar, S. Yanow, A. A. Best, and M. Lee, 2010, Synthesis and Antiprotozoal Activity of 1,2,3,4-Tetrahydro-2-Thioxopyrimidine Analogs of Combretastatin A-4, Med. Chem. Res. In Press.

153. L. Lee, L. M. Robb, M. Lee, R. Davis, H. Mackay, S. Chavda, B. Babu, E. L. O’Brien, A. L. Risinger, S. L. Mooberry, and M. Lee, 2010, Design, Synthesis and Biological Evaluations of 2,5-Diaryl-2,3-dihydro-1,3,4-oxadiazoline Analogs of Combretastatin-A4, J. Med. Chem. 53, 325-334.

154. K. A. Mitchum, R. Shalabi, K. H. Baxi, E. G. Mitchell, N. M. Lee, and E. V. Hestermann. 2010, Responses to Putative Aryl Hydrocarbon Receptor Antagonists, Toxicological Sciences Submitted.

155. C. J. Collar, M. Lee and W. D. Wilson, 2010, Setting anchor in the minor groove: in silico insight into formamido N-methylpyrrole and N-methylimidazole polyamides bound by cognate DNA sequences, J. Am. Chem. Soc. Submitted.

156. S. Chavda, K. Mulder, T. Brown, H. Mackay, B. Babu, L. Westrate, A. Ferguson, S. Lin, K. Kiakos, J. P. Ramos, M. Munde, W. D. Wilson, J. A. Hartley and M. Lee, 2010, DNA Recognition: Design, Synthesis and Biophysical Characteristics of Pyrrole(H) based Polyamides. Med. Chem. Submitted.

157. A. Franks, C. Tronrud, K. Kiakos, Y. Liu, T. Brown, H. Mackay, W. D. Wilson, J. A. Hartley and M. Lee, 2010, Targeting the ICB2 Site of the Topoisomerase IIa Promoter with a Formamido-Pyrrole-Imidazole-Pyrrole H-Pin Polyamide. Bioorg. Med. Chem. Submitted.

158. S. Chavda, B. Babu, C. Price, S. Hudson, S. Yanow, A. Jardim, K. Kiakos, J. A. Hartley, and M. Lee, 2010, A Novel Achiral seco-cyclopropylpyrido[e]indolone (CPyI) Analog of CC-1065 and the Duocarmycins: Synthesis, DNA Interactions, In Vivo Anticancer and Anti-parasitic Evaluation. Bioorg. Med. Chem. Submitted.


Presentations (78 before 2000)


79. R. Hubbard, M. Lee and P. Bowen, 2000, Novel Gene Control Agents Based on Distamycin – Design and Synthesis, University System of Georgia Research Symposium: Research and Application, Athens, GA.

80. A. Youngblood, K.A.O. Pacheco and M. Lee, 2000, Self-Assembled Monolayers and Biosensors: How Do They Stack Up?, Southeast Regional ACS Meeting, New Orleans.

81. M. Lee, K. Cox, C. Price and M. Le, 2001, Molecular Recognition of T-G Mismatched base pairs by Imidzole-Containing Analogs of Distamycin, 221st National ACS Meeting, San Diego.

82. K. Kiakos, N. Brooks, J.A. Hartley, J. Toth and M. Lee, 2001, Design, Synthesis, Cytotoxicity and Seqence Specificity of N-Methylpyrrole C and N-Terminus Linked seco-Cyclopropylindoline Hybrid Molecules, 92nd American Association for Cancer Research meeting, New Orleans.

83. K. Kiakos, N. Brooks, McHugh, P.J.; T. Howard, M. Lee and J.A. Hartley, 2001, Repair of Sequence Specific Adenine-N3 Alkylations in the Minor Groove of DNA, 92nd American Association for Cancer Research meeting, New Orleans.

84. E. Lacy, K.K. Cox, N.M. Le, C.A. Price, M. Lee and W.D. Wilson, 2001, Recognition of T-G Mismatches in DNA by Polyamides, Suddath Meeting, Atlanta, GA.

85. E. Madsen and M. Lee, 2001, Design of a Novel Heterodimeric Model for DNA Sequence Specific Recognition, Third Beckman Foundation Symposium, Irvine, CA.

86. H. Townes, K. Summerville, M. Hooker, B. Purnell, E. Madsen, S. Hudson and M. Lee. Selective Activation of Prodrugs of a Duocarmycin Analog by Reduction. 2001 Southeast ACS Meeting, Savannah, GA.

87. M. Le, C. Price, E. Lacy, M. Lee and W.D. Wilson. Influence of an N-Terminal Formamido Group on the Sequence Recognition of DNA by Polyamides. 2001 Southeast ACS Meeting, Savannah, GA.

88. B. Purnell, T. Howard, L. McNulty, B. Lingerfelt, H. Townes, H. Handl, K. Summerville, S. Hudson, P.J. Bowen, M. Lee, K. Kiakos, J. Hartley and M. Lee. The Design, Synthesis and Biological Evaluation of Novel iso-CFI and CFQ Analogs of CC-1065 and the Duocarmycins. 2001 Southeast ACS Meeting, Savannah, GA.

89. E. Madsen, C. Price, J. Toth, B. Lingerfelt, R.B. Hubbard III, H. Handl, S. Hudson, K. Kiakos, J. Hartley, P.J. Bowen and M. Lee, Molecular Recognition of DNA Sequence-Specific Alkylation by Conjugates of Hairpin Polyamide-Duocarmycin Analogs. 2001 Southeast ACS Meeting, Savannah, GA.

90. E.R. Lacy, S. Kim, M. Le, K.K. Cox, W.D. Wilson and M. Lee, Recognition of T.G Mismatched Base Pairs of DNA by Stacked Imidazole-Containing Polyamides: Surface Plasmon Resonance and Circular Dichroism Studies. 2001 Southeast ACS Meeting, Savannah, GA.

91. E. Lacy, S. Kim, K. Cox, M. Le, C. Price, D. Wilson and M. Lee, Recognition of T-G Mismatched Base Pairs of DNA by Stacked Imidazole Containing Polyamides: Surface Plasmon Resonance, CD and Isothermal Calorimetry Studies. 2002 Spring National ACS Meeting, Orlando, FL.

92. M. Le, E. Lacy, C. Price, M. Lee and D. Wilson, Influence of an N-terminal Formamido Group on the Sequence Recognition of DNA by Polyamides. 2002 Spring National ACS Meeting, Orlando, FL.

93. B. Purnell, B. Lingerfelt, A. Scott, H.Townes, K. Summerville, S. Hudson, K. Kiakos, J. Hartley and M. Lee, Novel (S)-(+)- and (R)-(-)-seco-iso-CFI Analogs of Duocarmycin C2. 2002 Spring National ACS Meeting, Orlando, FL.

94. B. Purnell, T. Howard, L. McNulty, B. Lingerfelt, H. Townes, H. Handl, K. Summerville, S. Hudson, M. Lee, K. Kiakos and J. Hartley, Novel seco-iso-CFI and seco-CFQ Analogs of the Duocarmycins: Design, Synthesis and Biological Evaluation. 2002 Spring National ACS Meeting, Orlando, FL.

95. H. Townes and M. Lee, Reductive Activation of Prodrugs of a CC-1065 Analog, 2002 Spring National ACS Meeting, Orlando, FL.

96. E. Madsen, J. Toth, C. Price, B. Lingerfelt, H. Handl, S. Hudson, K. Kiakos, J. Hartley and M. Lee, Molecular Recognition of DNA Sequence-Specific Alkylation by Conjugates of Hairpin Polyamide-Duocarmycin Analogs, 2002 Spring National ACS Meeting, Orlando, FL.

97. M. Lee, T. Hanks, L. Knight, Jr.,The Chemistry NSF-REU Site at Furman University, 2002 Spring National ACS Meeting, Orlando, FL.

98. E. Madsen and M. Lee, DNA Sequence-Specific Alkylation by Conjugates of Hairpin Polyamide-Duocarmycin Analogs, April 17, 2002, Western Carolinas Undergraduate Research Poster Session, Greenville, SC.

99. C. Howard, A. Collins and M. Lee, 2002, Synthesis and Photosensitization Properties of 1,5-Di(netropsin)- and 1,5-Di(lexitropsin)anthraquinone Conjugates. 16th National Conference on Undergraduate Research, University of Wisconsin at Whitewater.

100. C. Schlecht, H. Townes and M. Lee, 2002, Synthesis of a PSA-Activatable Tetrapeptide Prodrug of Anticancer Drugs, 16th National Conference on Undergraduate Research, University of Wisconsin at Whitewater.

101. J. Henry, Z. Taherbhai, J. Toth, K. Kiakos, J. Hartley, and M. Lee, 2002, Design, Synthesis, Cytotoxicity and Sequence Specificity of C- and N-Terminus Conjugates of N-Methylpyrrole Polyamides with seco-Cyclopropane, 2002 Southeast ACS Meeting, Charleston, SC.

102. A. Staples, M. Stewart, A. DiFrancesco, S. Mayalarp, S. Kim, A. Scott, J. Butler, and M. Lee, 2002, Synthesis and Biological Evaluation of Novel Diaziridinylquinone-acridine Conjugates, 2002 Southeast ACS Meeting, Charleston, SC.

103. R. Khan, H. Pati, R. Ayyad, A. DiFrancesco, J. Butler, K. Kiakos, J. Hartley, and M. Lee, 2002, Evaluation of a Novel DZQ-Polyamide Conjugate: Synthesis and Biological Properties. 2002 Southeast ACS Meeting, Charleston, SC.

104. P. McHugh, K. Kiakos, M. Lee, and J.A. Hartley, 2002, Rad6 and Rad18 Influence the Nucleotide Excision Repair of DNA Minor Groove Adducts, Conference on Yeast Genetics and Molecular Biology, Madison, Wisconsin.

105. A. Staples, M. Stewart, A. DiFrancesco, S. Mayalarp, S. Kim, A. Scott, J. Butler, and Error! Contact not defined., Design, Synthesis and Evaluation of a New Class of Diaziridinylquinones, 2003 Spring 225th National ACS Meeting, New Orleans, LA.

106. E. Lacy, J. Grandillo, M. Le, K. Kiakos, J.A. Hartley, D. Wilson, and M. Lee, Microcalorimetry and DNase I Footprinting Studies on the Molecular Recognition of T/G Mismatched Base Pairs of DNA by Stacked Polyamides, 2003 Spring 225th National ACS Meeting, New Orleans, LA.

107. H.N. Pati, A. DiFrancesco, S. Mayalarp, S. Kim, A. Scott, J. Butler, and M. Lee, Synthesis and Biological Evaluation of Novel Diaziridinylquinone-Acridine Conjugates, Feb 6, 2003, Indian 5th National Symposium in Chemistry, Madras, India.

108. M.T. Kotecha, L. Hercus, J. Henry, M. Le, C. Price, M. Lee, J.A. Hartley, and D. Hochhauser, 2003, Modulation of Topoisomerase II? Expression by Sequence Specific Polyamides, Annual Meeting of the American Association for Cancer Research, Toronto, Canada.

109. J. Toth, J. Trzupek, H. Handl, K. Summerville, S. Hudson, K. Kiakos, J. Hartley, and M. Lee. Novel Achiral Amino Analogs of CC-1065 and the Duocarmycins: Design, Synthesis and Biological Studies. 2003 Southeast ACS Meeting, Atlanta, GA.

110. H. Pati, R. LeBlanc, and M. Lee. An Efficient Method for the Synthesis of Substituted 4-Acetoxynaphthalene-2-carboxylate Esters, Ethyl 4-acetoxybenzofuran-6-carboxylate, and Ethyl 4-acetoxybenzothiophene-6-carboxylate. 2003 Southeast ACS Meeting, Atlanta, GA.

111. H. Pati, P. Weisbruch, A. Lemon, and M. Lee. Synthesis of N-Benzylated Anilines from the Reaction of Anilines and Benzyl Chloroformate. 2003 Southeast ACS Meeting, Atlanta, GA.

112. S. Horick, K. Buchmueller, C. Howard, M. Le, J. Henry, K. Cox, A. Staples, W.D. Wilson, and M. Lee. Selectivity and Specificity of DNA Minor Groove Binding Polyamides: A Practical Approach by Competitive Dialysis. 2003 Southeast ACS Meeting, Atlanta, GA.

113. J. Henry, S. Bailey, M. Le, B. Nguyen, K. Buchmueller, C. Howard, W.D. Wilson, and M. Lee. Selective Targeting of the Inverted CCAAT Box 2 by a Polyamide Hairpin. 2003 Southeast ACS Meeting, Atlanta, GA.

114. H. Pati, Z. Taherbhai, L. Forrest, M. Wicks, S. Bailey, A. Staples, M. Stewart, and M. Lee, A Stereospecific route for the Preparation of Trans-Combretastatin Analogs: Synthesis and Cytotoxicity. Jan 26, 2004, IUPAC International Conference, New Delhi, India.

115. K. Buchmueller, S. Horick, P. Uthe, A. Staples, K. Opperman-Pacheco, B. Nguyen, D. Wilson, and M. Lee, Influence of the Permutation of Imidazole and Pyrrole Moieties on the Binding Affinity of Polyamides to their Cognate and Non-cognate DNA Sequences. 2004 Spring National ACS Meeting, Anaheim, CA.

116. K. Buchmueller, P. Uthe, A. Staples, S. Bailey, B. Nguyen, D. Wilson, and M. Lee, Molecular Recognition of DNA Base Pairs by the Formamido/Pyrrole and Formamido/Imidazole Pairing in Stacked Polyamides. 2004 Spring National ACS Meeting, Anaheim, CA.

117. J. Henry, L. Flores, S. Bailey, D. Harris, Z. Taherbhai, K. Buchmueller, B. Nguyen, D. Wilson, M. Kocheta, D. Hochhauser, J. Hartley, and M. Lee, JH-37, a Hairpin Polyamide, Inhibits the Binding of Nuclear Factor-Y to Inverted CCAAT Boxes in the Human Topoisomerase II ? Promoter. A biochemical and biophysical study. 2004 Spring National ACS Meeting, Anaheim, CA.

118. K. Daniell, M. Stewart, E. Madsen, M. Le, H. Handl, N. Brooks, K. Kiakos, J. Hartley, and M. Lee, A Novel Class of Duocarmycin Analogs: Design, Synthesis and Biological Evaluation of Achiral Analogs of Duocarmycin SA. 2004 Spring National ACS Meeting, Anaheim, CA.

119. Z. Taherbhai, L. Forrest, M. Wicks, S. Bailey, A. Staples, M. Stewart, H. Pati, and M. Lee, A Stereospecific Route for the Preparation of Combretastatin Analogs: Synthesis and Cytotoxicity. 2004 Spring National ACS Meeting, Anaheim, CA.

120. C. Price, B. Lingerfelt, H. Handl, K. Kiakos, J. A. Hartley, and M. Lee. Design, Synthesis and DNA Alkylation Specificity of Novel Achiral seco-CI-Polyamide Hairpin Conjugates. National Meeting of the American Association for Cancer Research, Orlando, 2004.

121. K. Kiakos, P. J. McHugh, J. A.Hartley, A. Sato, S. Kim, K. Summerville, C. Price, and M. Lee. Design, Synthesis and Biological Evaluation of AS-I-145, a Novel Achiral amino seco-CBI. National Meeting of the American Association for Cancer Research, Orlando, 2004.

122. C. Price, B. Lingerfelt, H. Handl, K. Kiakos, J. A. Hartley, and M. Lee. DNA Sequence Specific Alkylation by Novel Chiral seco - CI - Polyamide Hairpin Conjugates. 2004, 56th Southeast Regional meeting of the ACS, Raleigh, NC.

123. K. Buchmueller, S. Horick, P. Uthe, A. Staples, K. Opperman-Pacheco, C. Bruce, J. Register, B. Nguyen, D. Wilson, and M. Lee Influence of Imidazole and Pyrrole Arrangement on the Binding Affinity of Polyamides to their Cognate and Non-cognate DNA Sequences. 2004, 56th Southeast Regional meeting of the ACS, Raleigh, NC.

124. K. Buchmueller, P. Uthe, A. Staples, S. Bailey, K. Blackmon, J. Jones, D. Matthews, B. Nguyen, D. Wilson, and M. Lee. DNA Base Pair Recognition by Formamido/Pyrrole and Formamido/Imidazole Pairings in Stacked Polyamides. 2004, 56th Southeast Regional meeting of the ACS, Raleigh, NC.

125. K. Daniell, M. Stewart, E. Madsen, M. Le, H. Handl, N. Brooks, K. Kiakos, J. Hartley, and M. Lee. A Novel Class of Duocarmycin Analogs: Design, Synthesis and Biological Evaluation of Achiral Analogs of Duocarmycin SA. 2004, 56th Southeast Regional meeting of the ACS, Raleigh, NC.

126. Z. Taherbhai, S. Bailey, A. Sutterfield, K. Buchmueller, B. Nguyen, D. Wilson, M. Kocheta, D. Hochhauser, J. Hartley, and M. Lee. ZT-65B, a Hairpin Polyamide that Binds to the Inverted CCAAT Box (ICB) Site of the Human Multidrug Resistant (mdr1) Gene. Design, Synthesis, and DNA Binding Studies. 2004, 56th Southeast Regional meeting of the ACS, Raleigh, NC.

127. R. LeBlanc, H.N. Pati, H. L. Holt, Jr., J. Dickson, M. Stewart, T. Brown, and M. Lee. Synthesis and Cytotoxic Properties of Nitro- and Aminochalcones. 2004, 56th Southeast Regional meeting of the ACS, Raleigh, NC.

128. L. Forrest, H. N. Pati, H. L. Holt, M. Wicks, S. Bailey, R. LeBlanc, M. Stewart, and M. Lee. Synthesis and Cytotoxicity of cis-Combrestatin Analogs and their Novel 1,2,3-Triazole Derivatives. 2004, 56th Southeast Regional meeting of the ACS, Raleigh, NC.

129. P. B. Uthe, A. M. Staples, M. Turlington, S. Bailey, J. Jones, K. Buchmueller, and M. Lee. Synthesis and DNA sequence recognition by picolinic acid-containing polyamides. 2004, 56th Southeast Regional meeting of the ACS, Raleigh, NC.

130. J. Dickson, L. Flores, P. Weisbruch, H. L. Holt, R. LeBlanc, M. Stewart, A. Onwuzurike, and M. Lee. Synthesis and Cytotoxic Properties of Chalcones: An Interactive Undergraduate Project at the Interface of Chemistry and Biology. 2004, 56th Southeast Regional meeting of the ACS, Raleigh, NC.

131. H. L. Holt, R. LeBlanc, J. Dickson, T. Brown, J. Maddox, and M. Lee. Unexpected Retro-Aldol Condensation of Chalcones. A Structure and Reactivity Study. 2004, 56th Southeast Regional meeting of the ACS, Raleigh, NC.

132. K. L. Buchmueller, P. Uthe, S. Bailey, D. Matthews, M, Lee, K. Cox, J. Register, C. Bruce, B. Bguyen, W. D. Wilson, and M. Lee. Thermodynamic and Structural Bases for the Binding of the Better-than-nature Triheterocyclic Polyamide f-ImPyIm to its Cognate Sequence, ACGCGT. 229th ACS National Meeting, San Diego, CA, March 13-17, 2005.

133. K. L. Buchmueller, P. B. Uthe, C. M. Howard, N. M. Le, K. K. Cox, S. L. Bailey, D. Matthews, J. Register, C. B. Bruce, B. Nguyen, C. O’Hare, J. A. Hartley, W. D. Wilson, and M. Lee. Reading the Language of Pyrrole- and Imidazole-Containing Polyamides that Recognize Specific DNA Sequences. 229th ACS National Meeting, San Diego, CA, March 13-17, 2005.

134. T. Brown, R. LeBlanc, J. Dickson, M. Stewart, H. N. Pati, H. L. Holt, Jr., W. T. Pennington, and M. Lee. Synthesis and Cytotoxicity Studies of Epoxide and Pyrazole Analogs of Combretastatins. 229th ACS National Meeting, San Diego, CA, March 13-17, 2005.

135. L. Forrest, D. Harris, and M. Lee. Design and synthesis of DH-21: An Imidazole/Pyrrole Containing Hairpin Targeting ATGA Sequences Within the DNA Minor Groove. 229th ACS National Meeting, San Diego, CA, March 13-17, 2005.

136. H. L. Holt, Jr., T. Brown, R. LeBlanc, J. Dickson, J. Maddox, and M. Lee. Unexpected Retro-Aldol Condensation of Chalcones. A Structure and Reactivity Study. Part II. 229th ACS National Meeting, San Diego, CA, March 13-17, 2005.

137. Z. Taherbhai, S. Bailey, A. Sutterfield, K. L. Buchmueller, M. Kotecha, D. Hochhauser, J.A. Hartley, B. Nguyen, W. D. Wilson, and M. Lee. ZT-65B, a Hairpin Polyamide that Binds to the Inverted CCAAT Box (ICB) site of the Human Multidrug Resistant (mdr1) Gene. Design, DNA Binding, and Biological Studies. 229th ACS National Meeting, San Diego, CA, March 13-17, 2005.

138. A. Sato, S. Kim, A. Scott, B. Purnell, V. Carnahan, H. Townes, B. Lingerfelt, L. McNulty, M. Ellington, W. Frazier, H. Handl, C. Price, K. Summerville, E. Madsen, S. Hudson, K. Kiakos, J. Hartley, M. Lee. A Novel Class of Duocarmycin Analogs: Design, Synthesis and Biological Evaluation of Achiral seco-CBI Analogs and CC-1065. 229th ACS National Meeting, San Diego, CA, March 13-17, 2005.

139. A. Bryant, K. King, H. Mackay, and M. Lee. Biophysical studies of pyrrole/imidazole tetraamides utilizing an ethidium bromide displacement assay. 2005, 57th Southeast/Southwest Regional meeting of the ACS, Memphis, TN.

140. A. Sutterfield, A. Bryant, C. Turlington, B. McNew, C. Groat,T. Brown, H. Mackay, and M. Lee. Synthesis and biophysical testing on non-formylated pyrrole/imidazole tetraamides. 2005, 57th Southeast/Southwest Regional meeting of the ACS, Memphis, TN.

141. J. Dickson, K. Baxi, R. Leblanc, T. Brown, M. Isenhower, M. Lee, and H. L. Holt, Jr. Synthesis and cytotoxic properties of cyclohexenone analogs of the combretastatins as potential vascular targeting agents. 2005, 57th Southeast/Southwest Regional meeting of the ACS, Memphis, TN.

142. M. Turlington, H. MacKay, C. Rutledge, B. Nguyen, D. Wilson, P.Weisbruch, M. Isenhower, and M. Lee. Synthesis and biophysical testing of a novel polyamide-benzamidine conjugate. 2005, 57th Southeast/Southwest Regional meeting of the ACS, Memphis, TN.

143. K. Buchmueller, S. Bailey, D. Matthews, Z. Taherbhai, J. Register, Z. Davis, C. D. Bruce, J. Hartley, M. Kotecha, D. Hochhauser, B.Nguyen, D.Wilson, and M. Lee. Physical Basis for the Strong Interactions Between the Polyamide, f-ImPyIm, and its Cognate DNA, ACGCGT. 2005, 57th Southeast/Southwest Regional meeting of the ACS, Memphis, TN.

144. L. V. Flores, A. M. Staples, H. Mackay, C. M. Howard, P. B. Uthe, J. S. Sexton III, K. L. Buchmueller, C. O’Hare, D. Hochhauser, J. A. Hartley, W. D. Wilson and M. Lee, 2006, Synthesis and evaluation of LVF-I-141: an intercalator-polyamide hairpin designed to target the inverted CCAAT box 2 in the topoisomerase II alpha promoter, 231st National ACS Meeting, Atlanta, GA.

145. T. Brown, Z. Taherbhai, J. Sexton, A. Sutterfield, M. Turlington, J. Jones, L. Stollings, M. Stewart, K. Buchmueller, H. Mackay, C. O'Hare, J. Hartley, B. Nguyen, D. Wilson and M. Lee, 2006, Synthesis and biophysical evaluation of minor-groove binding C-terminus modified polyamide derivatives of distamycin, 231st National ACS Meeting, Atlanta, GA.

146. J. Dickson, K. Baxi, T. Brown, H. Holt Jr., R. Le Blanc, L. Forrest and M. Lee, 2006, Synthesis and biological evaluation of cyclohexenone derivatives of combretastatin-A4 as potential tubulin inhibitors, 231st National ACS Meeting, Atlanta, GA.

147. A. Sato, A. Scott, T. Brown, H. Mackay, M. Lee, 2006, Efficient synthesis of achiral seco-hydroxy-cyclopropylbenz[e]indolone (CBI) and seco-amino-CBI analogs of the duocarmycins, 231st National ACS Meeting, Atlanta, GA.

148. K. Buchmueller, S. Bailey, D. Matthews, Z. Taherbhai, J. Register, Z. Davis, C. D. Bruce, J. A. Hartley, M. Kotecha, D. Hochhauser, B. Nguyen, D. Wilson and M. Lee, 2006, Molecular recognition of polyamides with DNA: A study on the strong binding of f-ImPyIm to its Cognate DNA, ACGCGT, 231st National ACS Meeting, Atlanta, GA.

149. J. Register, Z. S. Davis, C. D. Bruce, K. Buchmueller, B. Nguyen, W. D. Wilson and M. Lee, 2006, Molecular dynamics simulation of a polyamide minor groove binder of DNA, 231st National ACS Meeting, Atlanta, GA

150. A. Sielaff, A. Cooper, H. Mackay, T. Brown, C. O'hare, J. Hartley and M. Lee, 2007, Binding of f-PIP to the inverted CCAAT box-2 of the topoisomerase II??promoter, 233rd National ACS Meeting, Chicago, IL.

151. L. Westrate, H. Mackay, B. Nguyen, W. D. Wilson, J. Kluza, J. Hartley, T.Brown and M. Lee, 2007, Investigating the role of the N-terminus formamido group of distamycin, 233rd National ACS Meeting, Chicago, IL.

152. L.P. Nolan, K. Mulder, J. Martinez, T. Smith, T. Brown and M. Lee, 2007, Synthesis of novel polyamide acids as intermediates for anti-cancer compounds, 233rd National ACS Meeting, Chicago, IL.

153. B. Younglove, L. Lee, H. Mackay, S. Moobury, T. Brown and M. Lee, 2007, Pyrazoline analogs of Combretastatin A-4: Synthesis, biological evaluation and tubulin inhibition, 233rd National ACS Meeting, Chicago, IL.

154. J. Ruprich, A. Prout, J. Dickson, B. Younglove, H. Mackay, K. Baxi, H. Holt Jr., R. Le Blanc, L. Forrest, S. L. Mooberry, T. Brown and M. Lee, 2007, Synthesis, in vitro tubulin inhibition and cell cytotoxicity of cyclohexenone derivatives of combretastatin-A4, 233rd National ACS Meeting, Chicago, IL.

155. K. Mulder, J. Sexton, L. P. Nolan, Z. Taherbhai, J. Jones, P. Uthe, T. Brown and M. Lee, 2007, Building blocks for polyamide synthesis: N-Formamido-containing mono- and diheterocyclic pyrrole- and imidazole-2-carboxylic acids, 233rd National ACS Meeting, Chicago, IL.

156. J. Lajiness, P. Uthe, H. Mackay, J. Jones, K. Blackmon, C. O'Hare, J. Hartley, B. Nguyen, W. D. Wilson, T. Brown and M. Lee, 2007, Synthesis and biophysical evaluation of a series of H-pin polyamides designed to bind in a staggered motif to duplex DNA, 233rd National ACS Meeting, Chicago, IL.

157. T. Bultman and M. Lee, April 19-21, 2007, Building an Interdisciplinary Research Program Involving Undergraduate Students: A Bridge for Students to Scientific Inquiry in the 21st Century, AAC&U Meeting on The Student as Scholar: Undergraduate Research and Creative Practice, Long Beach, CA.

158. J. Sexton III, T. Brown, H. Mackay, M. Kotecha, C. O’Hare, J. Kluza, D. Hochhauser, J. A. Hartley, B. Nguyen, W. D. Wilson and M. Lee, 2007, Regulation of the topoisomerase II? gene using polyamides that binds to the inverted CCAAT box present in the promoter. 234th National ACS Meeting, Boston, MA.

159. T. Brown, H. Mackay, M. Turlington, A. Sutterfield, T. Smith, L. Westrate, A. Sielaff, C. Bruce, C. O'Hare, J. A. Hartley, B. Nguyen, W. D. Wilson and M. Lee, 2007, Modifications of the N-terminus of polyamides resulted in compounds with enhanced DNA binding sequence specificity. 234th National ACS Meeting, Boston, MA.

160. L.A., Purcell, S.K., Yanow, G., Pradel, A., Rodriguez, M. Lee, and T.W. Spithill, May 2007, The transmission-blocking activities of a potent new antimalarial. Canadian Society of Zoologists Annual Meeting, Montreal, QC: Canadian Society of Zoologists Bulletin 38-02.

161. Alan Sielaff, Jamie Lajiness, Hilary Mackay, Toni Brown and Moses Lee
Investigating the Importance of Polyamide Curvature in DNA-Polyamide Binding, Summer Research Symposium, Notre Dame University, IN, August 2007.

162. L. E. Lee, R. Davis, J. VanderHam, H. Mackay, T. Brown, P. Hills, S. L. Mooberry and M. Lee, 2007, Synthesis, cytotoxicity and anti-mitotic properties of 1,2,3,4-tetrahydro-2-thioxopyrimidine analogs of combretastatin-A4. Southeast Regional ACS Meeting, Greenville, SC, October 2007.

163. L. N. Wang, H. Mackay, T. Brown and M. Lee, 2007, Targeting the Inverted CCAAT Box-2 of the Topoisomerase II? Gene Using a Polyamide Conjugated with a “Threading” Unit. Southeast Regional ACS Meeting, Greenville, SC, October 2007.

164. S.K. Yanow, L.A. Purcell, G. Pradel, A. Rodriguez, M. Lee and T.W. Spithill, 2007, Potent Antimalarial and Transmission-blocking Activities of a Novel DNA Binding Agent, Centanamycin, Royal Society of Tropical Medicine and Hygiene at the Centenary Conference in London, U.K., September 2007.

165. T. Brown, Z. Taherbhai, J. Sexton, A. Sutterfield, M. Turlington, J. Jones, L. Stollings, M. Stewart, K. Buchmueller, H. Mackay, C. O'Hare, J. Hartley, B. Nguyen, D. Wilson and M. Lee, 2006, Synthesis and biophysical evaluation of minor-groove binding C-terminus modified polyamide derivatives of distamycin, West Michigan Undergrad Research Conference, Van Andel Research Institute, Grand Rapids, MI, October 23, 2007.

166. A. Sielaff, A. Cooper, H. Mackay, T. Brown, C. O'Hare, J. Hartley and M. Lee, 2007, Binding of f-PIP to the inverted CCAAT box-2 of the topoisomerase II??promoter, West Michigan Undergrad Research Conference, Van Andel Research Institute, Grand Rapids, MI, October 23, 2007.

167. L. A. Purcell, S. K. Yanow, G. Pradel, A. Rodriguez, M. Lee and T. W. Spithill, 2007, Developmental Arrest of Malaria Parasites in Mosquitoes Following Treatment of Mice with AS-I-145. American Society of Tropical Medicine and Hygiene 56th Annual Meeting, Philadelphia, Pennsylvania, USA, November 4-8, 2007.

168. M. Lee and J. N. Boelkins, Liberal Arts: The Foundation of a Science Education at Hope College. American Conference for Academic Deans – Phi Beta Kappa Conference, Washington, D.C. October 25-27, 2007.

169. R. Davis, H. Mackay, T. Brown, H. Pati, U. Das, J. Dimmock, S. Mooberry and M. Lee, 2008, Syntheses and Cytotoxic Properties of the Curcumin Analogs 2,6-Bis(benzylidene)-4-Phenylcyclohexanones. Southeast Regional ACS Meeting, Nashville, TN, and 2nd Annual West MI Regional Science Undergraduate Science Research Conference, Van Andel Research Institute, Grand Rapids, MI.

170. K. Dittenhafer, S. Canche, T. Brown, H. Mackay, B. Strong, D. Desta and M. Lee, 2008, Synthesis of 1,2,3,4-Tetrahydro-2-Thioxopyrimidine-4,6-Diaryldiamidines to Target A/T Rich Sequences of DNA in Parasites. Southeast Regional ACS Meeting, Nashville, TN, and 2nd Annual West MI Regional Science Undergraduate Science Research Conference, Van Andel Research Institute, Grand Rapids, MI.

171. A. Franks, C. Tronrud, L. Westrate, R. Davis, A. Ferguson, T. Brown, H. Mackay, J. Kluza, J. A. Hartley, M. Munde, D. Wilson and M. Lee, 2008, Design and Synthesis of An f-PIP H-Pin Polyamide That Targets the ICB2 Topoisomerase IIa Promoter. Southeast Regional ACS Meeting, Nashville, TN, and 2nd Annual West MI Regional Science Undergraduate Science Research Conference, Van Andel Research Institute, Grand Rapids, MI.

172. R. Davis, L. Lee, M. Lee, H. Mackay, T. Brown, S. Mooberry and M. Lee, 2008, Anticancer and Tubulin Inhibition Properties of Novel Oxadiazoline Analogs of Combertastatin-A4. Southeast Regional ACS Meeting, Nashville, TN.

173. C. Tronrud, A. Franks, A. Plaunt, R. Ogilvie, C. Riddering, T. Brown, H. Mackay and M. Lee, 2008, Optimizing the Synthesis of Minor Groove Binding Heterocyclic Polyamides. Southeast Regional ACS Meeting, Nashville, TN, and 2nd Annual West MI Regional Science Undergraduate Science Research Conference, Van Andel Research Institute, Grand Rapids, MI.

174. Ross Ogilvie, A. Plaunt, C. Riddering, L. Westrate, R.Davis, A. Ferguson, S. Chavda, H. Mackay, T. Brown, D. Wilson, J. A. Hartley and M. Lee, 2009, Design, Synthesis and DNA Binding Properties of Orthogonally Positioned Diamino-Containing Polyamides, ACS National Meeting, Salt Lake City, UT.

175. R. Davis, A. Sielaff, J. Ruprich, L. Westrate, C. Tronrud, A. Ferguson, T. Brown, H. Mackay, J. Kluza, Y. Liu, D. Wilson, J. A. Hartley and M. Lee, 2009, Design, Synthesis, Biophysical and Biological Studies of Fluorescent Hoechst-Polyamide Hybrid Molecules, ACS National Meeting, Salt Lake City, UT.

176. M. Li, E. Rayburn, W. Wang, F. Wang, J. M. Covey, M. Lee and R. Zhang, 2009, Preclinical Pharmacological Evaluations of Indolecarboxamine ML-970 (NSC 716970), 100th Annual American Association Cancer Society Meeting, Denver, CO.

177. K. Mulder, T. Brown, H. Mackay, S. Chavda, B. Babu, D. Wilson, J. Hartley and M. Lee, 2009, DNA sequence Selective Recognition by the Pyrrole(H)/N-Methylpyrrole and Pyrrole(H)/N-Methylimidazole: Design, Synthesis and Biophysical characteristics, ACS National Meeting, Washington, D.C.

178. B. Babu, L. Forrest, S. Chavda, H. Pati and M. Lee, 2009, Synthesis and Cytotoxicity of 1-Phenylethanolamine Carboxamide Derivatives: Effects on the Cell Cycle, ACS National Meeting, Washington, D.C.

179. D. Desta, K. Dittenhafer, L. Lee, S. Canche, S. Chavda, B. Babu, A. Best, S. L. Mooberry, S. Yanow, and M. Lee, 2009, Synthesis and Antiprotozoal Activity of 1,2,3,4-Tetrahydro-2-Thioxopyrimidine Analogs of Combretastatin A-4, ACS National Meeting, Washington, D.C.

180. M. Lee, L. Lee, R. Davis, H. Mackay, S. Chavda, Y. P. Acosta, S. L. Mooberry and M. Lee, 2009, Anticancer and Tubulin Inhibition Properties of Novel Oxadiazoline Analogs of Combertastatin-A4, ACS National Meeting, Washington, D.C.

181. S. Chavda, R. Davis, A. Ferguson, H. Mackay, C. Riddering, B. Babu, W. Pennington, A. Siegfried, S. L. Mooberry, Y. P. Acosta, M. Lee and H. N. Pati, 2009, On the Synthesis and Anticancer Testing of a,ß-Unsaturated Ketones as Analogues of Combretastatin-A4, ACS National Meeting, Washington, D.C.

182. S. Chavda, J. Eames, M. Lee and Y. Yohannes, 2009, Probing the Resolutions of 2- Alkoxy and 2-Aryloxy Carboxylic Acids, ACS National Meeting, Washington, D.C.

183. M. Lee, R. Davis, H. MacKay, S. Chavda, B. Babu, L. M. Robb, E. L. O'Brien, A. L. Risinger, S. L. Mooberry, and M. Lee, 2009, Design, Synthesis, and Biological Testing of Oxadiazoline Analogs of Combertastatin-A4, Southeast Regional ACS Meeting, San Juan, Puerto Rico.

184. D. Denby, A. Phillips, P. N. Larsen, S. Chavda, M. J. Misovich and M. N.F. Lee, 2009, The Chemistry behind the Conversion of Vegetable Oils to Biodiesel, AIChE Annual Meeting, Nashville, TN

185. A. R. Phillips, P. N. Larsen, D. Denby, S. Chavda, M. N.F. Lee and M. J. Misovich, 2009, Optimizing Pilot Plant Biodiesel Production, AIChE Annual Meeting, Nashville, TN

186. K. Kiakos, J. Ruprich, R. Davis, A. Sielaff, L. Westrate, C. Tronrud, A. Ferguson, T. Brown, H. Mackay, M. Lee, Y. Liu, D.Wilson, D. Hochhauser, J. A. Hartley, 2010, Pharmacological modulation of Topoisomerase IIa expression and confluence-induced resistance to etoposide by a novel fluorescent HxIP polyamide, 101st American Association for Cancer Research, Washington, D.C.

187. E. Rayburn, W. Wang, S. Grau, H. Li, H. Xu, X. Zhang, M. Li, C. Sommers, L.
Jia, M. Lee, R. Zhang. 2010, Enterohepatic circulation of indolecarboxamide ML-970 (NSC 716970), an investigative anticancer agent, 101st American Association for Cancer Research, Washington, D.C.


Invited Talks (23 before 2000)


24. M. Lee, January 29, 2000, Targeting Unique DNA sequences by Novel ‘Hairpin’ Duocarmycin-Lexitropsin Conjugates: Molecular Design and Applications, University of Richmond, Richmond, VA.

25. M.Lee, April 20, 2000, Control of gene Expression – Application to Cancer Treatment, Erskine College, Due West, SC.

26. M. Lee, December 8, 2000, Second Generation CBI Analogs of CC-1065 and The Duocarmycins, Taiho Pharmaceutical Co., Inc., Tokyo, Japan.

27. M. Lee, March 22, 2001, Novel seco-Analogs of CBI and Duocarmycins SA, National Cancer Institute, Frederick, Maryland.

28. M. Lee, March 31, 2001, Recognition of T-G Mismatches in DNA by Polyamides, Wake Forest University Baptist Medical Center, Lown Symposium, Winston-Salem, NC.

29. M. Lee, August 2, 2001, Novel seco-Cyclopropanefuranoindoline Analogs of the Duocarmycins and CC-1065: Design, Synthesis, and Biological Evaluation, St. Jude Children’s Research Hospital, Memphis, TN.

30. M. Lee, September 23, 2001, The Biochemistry/Chemistry Program at Furman University. 2001 Southeast ACS Meeting, Savannah, GA.

31. M. Lee, October 10, 2001, Design, Synthesis and Biological Evaluations of Novel seco-Cyclopropanefuranoindoline Analogs of the Duocarmycins and CC-1065. College of Pharmacy, University of South Carolina, Columbia, SC.

32. M. Lee, March 1, 2002, Molecular Recognition of Watson-Crick and T/G Mismatched Base Pairs of DNA by Stacked Polyamides, Western Washington University, Bellingham, WA.

33. M. Lee and L.B Knight, Jr., 2002, Undergraduate Research, the Departmental Focus and the Institutional Mission: Challenges and Opportunities. 2002 Spring National ACS Meeting, Orlando, FL.

34. M. Lee, June 4, 2002, Studies on the Sequence Specific Recognition of Minor Groove Binding Agents to DNA: Design and Potential Applications, GlaxoSmithKline, Research Triangle Park, NC.

35. M. Lee, October 9, 2002, Discovery of the Molecular Recognition of T/G Mismatched Base Pairs of DNA by Stacked Polyamides, and Its Potential Applications, University of Guelph, Guelph, Canada.

36. M. Lee, October 22, 2002, Discovery of the Molecular Recognition of T/G Mismatched Base Pairs of DNA by Stacked Polyamides, and Its Potential Applications, National Science Foundation, Arlington, VA.

37. M. Lee, S. Kupchinsky, S. Centioni, T. Howard, J. Trzupek, S. Roller, C. Price, H. Handl, K. Summerville, K. Johnson, J. Toth, N. Brooks, K. Kiakos, and J. Hartley, November 14, 2002, A New Class of CC-1065 and Duocarmycin Analogs: Design, Synthesis and Biological Properties, Nucleic Acids Symposium, 2002, Southeast ACS Meeting, Charleston, SC.

38. M. Lee, March 3, 2003, Discovery of the Molecular Recognition of T/G Mismatched Base Pairs of DNA by Stacked Polyamides, and Its Potential Applications, University of North Carolina at Charlotte, NC.

39. M. Lee, March 23, 2003, A Presentation of the Medicinal Chemistry Course at Furman University, A symposium on the Teaching of Medicinal Chemistry to Undergraduate Chemistry Students, Spring 225th National ACS Meeting, New Orleans, LA.

40. M. Lee, September 7 – 11, 2003, Characterizing the Molecular Recognition of Watson-Crick and T/G Mismatched Base Pairs by Stacked Polyamides, Frontiers in DNA Research Symposium, Fall 226th National ACS Meeting, New York City, NY.

41. M. Lee, September 7 – 11, 2003, Where would Chemistry and Biology Meet? Gene Expression Control by Small molecules, The Interface of Chemistry and Biology Symposium, Fall 226th National ACS Meeting, New York City, NY.

42. M. Lee, October 2, 2003, A New Class of Analogs of CC-1065 and Duocarmycins: Design, Synthesis, Biochemical and Biological Evaluation, University of Northern Colorado, Greeley, CO.

43. M. Lee, November 12, 2003, Sequence Specific Recognition of Watson-Crick and Abnormal DNA, & Future of Chemistry Research, Research Corporation, Tucson, AZ.

44. S. Kupchinsky, S. Centioni, T. Howard, J. Trzupek, S. Roller, C. Price, H. Handl, K. Summerville, K. Johnson, J. Toth, S. Hudson, N. Brooks, K. Kiakos, J. Hartley, and M. Lee. A New Class of Achiral Analogs of CC-1065 and the Duocarmycins. 2003 Southeast ACS Meeting, Atlanta, GA.

45. M. Lee, November 20, 2003, A New Class of Analogs of CC-1065 and Duocarmycins: Design, Synthesis, Biochemical and Biological Evaluation, University of Maryland, College Park, Maryland.

46. M. Lee, and J. Pemberton, March 2004, Partnerships and collaborations are key features in the creation of undergraduate research centers (URCs). 2004 Spring National ACS Meeting, Anaheim, CA.

47. M. Lee, June 1, 2004, Sequence Specific Recognition of DNA: Molecular Design and Applications, Department of Oncology, Royal Free & University College Medical School, London, UK.

48. M. Lee, September 24, 2004, A New Class of Analogs of CC-1065 and Duocarmycins: Design, Synthesis, Biochemical and Biological Evaluation, Claflin University, Orangeburg, SC.

49. M. Lee, October 22, 2004, An Overview of Drug Discovery Projects in the Lee Group at Furman University. Meeting on Drug Discovery in SC, Charleston, SC.

50. M. Lee, December 1, 2004, Exploration of DNA Sequence Specific Molecular Recognition by Small Molecules: From Design and Synthesis, to Biochemistry and Application. East Carolina University, Greenville, NC.

51. M. Lee, January 24, 2005, Exploration of DNA Sequence Specific Molecular Recognition by Small Molecules: From Design and Synthesis, to Biochemistry and Application. St. Edward’s University, Austin, TX.

52. M. Lee, February 11, 2005, Exploration of DNA Sequence Specific Molecular Recognition by Small Molecules: From Design and Synthesis, to Biochemistry and Application. Hope College, Holland, MI.

53. T. Hanks, and M. Lee, March 13-17, 2005, The Grand Challenges of Chemistry: Research experiences for Student/Faculty teams at Furman University. 229th ACS National Meeting, San Diego, CA.

54. M. Lee, December 13, 2005, The Future of Science in the Nation Begins with Us: A Hope Contribution, Holland Chamber of Commerce, Holland, MI.

55. M. Lee, February 4, 2006, Where do Medicines Come from? Winter Happenings, Hope College, Holland, MI.

56. M. Lee, March 3, 2006, Developing a Language for DNA Sequence Specific Recognition by Polyamides, Butler University, Indianapolis, IN.

57. M. Lee, March 24, 2006, A New Generation of (+)-CC-1065 and the Duocarmycins Analogs: Design, Synthesis, Biological Evaluation, University of Georgia, Athens, GA.

58. M. Lee, September 1, 2006, Interdisciplinary Research at Hope College, Hope College Annual HHMI Celebration, Holland, MI.

59. M. Lee, September 5, 2006, Developing a Language for DNA Sequence Specific Recognition by Pyrrole-and Imidazole-containing Polyamides, Faculty of Pharmacy, Wayne State University, Detroit, MI.

60. M. Lee, September 22, 2006, Design, Synthesis, and Biological Evaluation of (+)-CC-1065 and (+)-Duocarmycins Analogs, Illinois State University, Normal, IL.

61. M. Lee, November 1-4, 2006, Adjusting the Kinetics and Thermodynamics Properties for the Binding of Polyamides to an Inverted CCAAT Box Present in the Promoter of the Topoisomerase II? Gene, “Nucleic Acids Symposium.” Southeast Regional ACS Meeting, Augusta, GA.

62. M. Lee, December 7-10, 2006, Regulation of the Topoisomerase II? Gene Using Polyamides that Binds to the Inverted CCAAT Box Present in the Promoter. Ninth Annual Kavli Japanese-American Frontiers of Science Symposium, National Academy of Sciences, Beckman Institute, Irvine, CA.

63. M. Lee, January 23, 2007, Interdisciplinary Research at the Frontier of Science. Hope Academy of Senior Professionals (HASP) "What's New In Science" series. Hope College, Holland, MI.

64. M. Lee, January 30, 2007, Regulation of the Topoisomerase II? Gene Using Polyamides that Binds to the Inverted CCAAT Box Present in the Promoter. The Van Andel Research Institute - Han-Mo Koo Lecture Series, Grand Rapids, MI.

65. M. Lee, April 11, 2007, Panel Discussion on Demystifying The Process of Getting Tenure. Chemistry Department, University of Michigan, Ann Arbor, MI.

66. C. C. O’Hare, P. Uthe, H. Mackay, K. Blackmon, J. Jones, T. Brown, L. Westrate, A. Sielaff, J. P. Lajiness, B. Nguyen, W. D. Wilson, J. A. Hartley and M. Lee, August 2007, Sequence recognition in the minor groove of DNA by covalently linked formamido-imidazole-pyrrole-imidazole polyamides: the effect of H-pin linkage and linker length on selectivity and affinity. 234th National ACS Meeting, Division of Carbohydrate Chemistry, “Nucleic Acids as Drug Targets symposium,” Boston, MA.

67. M. Lee, July 3, 2007, Opportunities for Cancer Research at Hope College. Hope Academy of Senior Professionals (HASP) Presentation. Hope College, Holland, MI.

68. T. Brown, H. Mackay, A. Sutterfield, L. Westrate, A. Sielaff, A. Cooper, A. Bryant, J. Kluza, J. Hartley, B. Nguyen, D. Wilson and M. Lee, October 25, 2007, Tetraamide Polyamides: Extending the Language of DNA Sequence Selective Recognition, “Nucleic Acids Symposium.” Southeast Regional ACS Meeting, Greenville, SC.

69. M. Lee, November 7, 2007, Targeting Specific DNA Sequences by Small Molecules: Opportunities for the Discovery of New DNA-Based Therapeutics and Diagnostics. Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, NC.

70. M. Lee, November 26, 2007, Targeting Specific DNA Sequences by Small Molecules: Opportunities for the Discovery of New DNA-Based Therapeutics. Department of Chemistry, University of Richmond, Richmond, VA.

71. M. Lee, February 20, 2008, An Update on the Natural & Applied Sciences Division at Hope College. Hope College Advancement Luncheon with Alumni, Parents and Friends of the Hope College, Grand Rapids, MI.

72. M. Lee, April 6, 2008, Centanamycin: A Powerful New Anti-malarial Agent that Targets the Minor Groove of the A/T rich Plasmodium Genome. Symposium for the ACS Award for Research at an Undergraduate Institution, Spring 2008 National ACS Meeting, New Orleans.

73. M. Lee, April 7, 2008, The Beckman Scholars Program: Impact on the Awardees, the Mentor’s Research Program, and the Department. Celebrating Ten Years of Beckman Scholars in Chemistry, Presidential Symposium. Spring 2008 National ACS Meeting, New Orleans.


74. M. Lee, April 16, 2006, Entrepreneurial Science. A Presentation to the Retirees Group of Hope College, Holland, MI.

75. M. Lee, April 18, 2008, Undergraduate Research, The Future of STEM Education: An Example in Malaria Research, Mercer University Undergraduate Research Symposium Keynote Lecture, Mercer University, Macon, GA.

76. M. Lee, May 3, 2008, Centanamycin: A Potentially New Anti-malarial Drug. Hope College Alumni Weekend Presentation, Hope College, Holland, MI.

77. M. Lee, June 26, 2008, Discovery of New DNA-Targeted Gene Control Agents: Reliance on Innovation in Scientific Instrumentation, NSF and NIH Workshop on Instrument Development, Washington, D.C.

78. M. Lee, August 13, 2008, Hope College: Recognized Excellence, Midland, MI.

79. M. Lee, November 1, 2008, Developing Anti-Malaria Drugs, West Michigan Regional Undergraduate Science Research Conference, Van Andel Research Institute, Grand Rapids, MI

80. M. Lee, November 8, 2008, Development of ML-970 as a Potential Anticancer Drug, NCI Translates, NCI Translational Science Meeting, Washington, D.C.

81. M. Lee, November 24, 2008, Sequence Specific Recognition of DNA by Small
Molecules: Discovery of New DNA-based Anticancer and Antimalarial Drugs, Wake Forest University, Salem, NC

82. M. Lee, February 6, 2009, Recognition of Specific DNA Sequences by Small
Molecules: Opportunities for the Discovery of New DNA-Based Therapeutics.
Department of Chemistry, Hamilton College, Clinton, NY.

83. M. Lee, March 24, 2009, Sequence Specific Recognition of DNA by Small Molecules in
the Minor Groove: Examples of Biological Applications, National ACS Award, Symposium for ACS Award for Research at an Undergraduate Institution, ACS National Meeting, Salt Lake City, UT.

84. M. Lee, April 2, 2009, Opportunities of Research at a PUI: Developing Anti-Malaria
Drugs, 2009 CUR Dialogues, Alexandria, VA

85. M. Lee, April 3, 2009, Research Corporation New Programs, 2009 CUR Dialogues, Alexandria, VA

86. M. Lee, August 12, 2009, Hope College, Natural and Applied Sciences Division: A Year of Distinctives, Midland, MI.

87. M. Lee, September 18, 2009, Design of Polyamides for DNA Sequence Specific Binding and Application in Gene Control and Anticancer Drug Design, Department of Biochemistry, University of Missouri, Columbia, MO

88. M. Lee, September 17, 2009, A Great Year for Hope – NAS. Hope College alumni and friends, University of Missouri, Columbia, MO

89. R. Davis, J. Ruprich, A. Sielaff, L. Westrate, C. Tronrud, A. Ferguson, T. Brown, H. Mackay, S. Chavda, B. Babu, K. Kiakos, J. Kluza, Y. Liu, D. Wilson, J. A. Hartley, and M. Lee, October 22, 2009, A New DNA Base Pair Recognition Element: Sequence Specificity, Cell Uptake and Biological Activity, Southeast Regional ACS Meeting, San Juan, Puerto Rico.

90. M. Lee, January 8, 2010, Centanamycin, A Novel Anti-Malarial Agent: Design, Synthesis, and Drug Development, Department of Chemistry, Nanyang Technical University, Singapore.

91. M. Lee, January 8, 2010, Centanamycin, A Novel Anti-Malarial Agent: Design, Synthesis, and Drug Development, Michigan State University Bioeconomy Institute, Holland, MI.

92. M. Lee, February 23, 2010, Transformative Chemistry and Biology Research: Application of New Science in the Design and Development of Anticancer and Antiparasitic Agents. The Council on Undergraduate Research (CUR), in conjunction with the House Science, Technology, Engineering and Mathematics (STEM) Education Caucus, cordially invites policymakers and staff to a luncheon briefing on “Transformative Research at Undergraduate Institutions: The Capacity to Revolutionize,” B338 Rayburn House Office Building, Washington, D.C.