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Picture of Maria A. Burnatowska-Hledin Maria A. Burnatowska-Hledin Professor of Biology and Chemistry


  • Sutton, R.A.L., Burnatowska, M.A., Wong, N.L.M., Dirks, J.H.: Effects of Vitamin D and PTH on distal tubular calcium reabsorption. Urolithiasis Research, (ed) Fleish, J., et al.: 95-96, 1976.
  • Burnatowska, M.A., Harris, C.A., Sutton, R.A.L., Dirks, J.H.: Effects of PTH and cAMP on renal handling of calcium, magnesium and phosphate in the hamster. Am. J. Physiol. 22:F514-518, 1977.
  • Sutton, R.A.L., Harris, C.A., Burnatowska, M.A.. Quamme, G.A., Dirks, J.H.: Parathyroid hormone and renal calcium and magnesium transport in the hamster. In: Endocrinology and Calcium Metabolism, D.H. Copp, ed., Excerpta Medica, Amsterdam: 91. 1978.
  • Harris, C.A., Burnatowska, M.A., Seely, J.F., Quamme, G.A., Sutton, R.A.L., Dirks, J.H.: Effects of parathyroid hormone (PTH) on electrolyte transport in the hamster. Am. J. Physiol. 26:F42-48, 1979.
  • Mayor, G.H., Burnatowska-Hledin, M.A.: Impaired renal function and aluminum metabolism. Fed. Proc. 42:2979-298, 1983.
  • Burnatowska-Hledin, M.A., Kaiser, L., Mayor, G.H.: Aluminum, parathyroid hormone, and osteomalacia. Special topics in endocrinology and metabolism (eds. M.P. Cohen, P.P. Foa) 5:201-227, 1983.
  • Kaiser, L., Burnatowska-Hledin, M.A., Schwartz, K.A., Mayor, G.H.: Microcytic anemia secondary to intraperitoneal aluminum in normal and uremic rats. Kidney International 26:269-274, 1984.
  • Burnatowska-Hledin, M.A., Mayor, G.H.: The effects of sucralfate ingestion of plasma and specific tissue aluminum accumulation in normal rats. Clinical Toxicology 22:87-93, 1984.
  • Burnatowska-Hledin, M.A., Mayor, G.H.: The effects of aluminum loading on specific tissue calcium and magnesium concentrations in normal rats. Biological Trace Element Research 7:51-55, 1985.
  • Burnatowska-Hledin, M.A., Klein, A.M., Mayor, G.H.: Effect of aluminum on the renal handling of phosphate in the rat. Am. J. Physiol.: Renal Fluid and Electrolyte Physiology 248:F64-69, 1985.
  • Burnatowska-Hledin, M.A., Harris, C.A., Sutton, R.A.L., Seely, J.F.: The effects of Vitamin D on renal handling of calcium, magnesium and phosphate in the hamster. Kidney International 27:864-870, 1985.
  • Burnatowska-Hledin, M.A., Mayor, G.H., Lau, K.: Renal handling of aluminum: Clearance and micropuncture studies, Am. J. Physiol, 249:F192-F197, 1985.
  • Henriquez, M., Burnatowska-Hledin, M.A., Clark, M.J., Mayor, G.H.: Evaluation of aluminum binding to hollow fiber dialyzer. Am. J. Kidney Diseases 7:217-220, 1985.
  • Swartz, R., Dombrouski, J., Burnatowska-Hledin, M.A., Mayor, G.H.: Microcytic anemia in dialysis population patients: Reversible marker of aluminum toxicity. Proc. EDTA 22:101-105, 1985.
  • Burnatowska-Hledin, M.A., Mayor, G.H.: Aluminum: Analytical considerations. Am. J. Kidney Diseases VI:28-287, 1985.
  • Mayor, G.H., Burnatowska-Hledin, M.A.: Aluminum is becoming a burden. Am. J. Kidney Diseases, VI:281-288, 1985.
  • Gilbert, H.M., Lohr, T.O., Sanchez, T.V., Burnatowska-Hledin, M.A. Aluminum metabolism and toxicity in renal failure: A review. IEPTO 6:1/43-50, 1985.
  • Burnatowska-Hledin, M.A., Doyle, T., Eadie, M., Mayor, G.H.: Effects of 1,25(OH)-2D on tissue aluminum accumulation in normal rats. J. Clin. Lab. Med. 108:96-102, 1986.
  • Burnatowska-Hledin, M.A., Ebner, K.V., Mayor, G.H.: Effects of aluminum on rat liver mitochondrial function. Biological Trace Element Research 10:235-242, 1986.
  • Burnatowska-Hledin, M., Mayor, G.H.: The metabolism of aluminum-related encephalopathy. Seminars in Nephrology 6:1-5, 1986.
  • Swartz, R., Dombrouski, R. J., Burnatowska-Hledin, M.A., Mayor, G.H.: Microcytic anemia in dialysis patients: Reversible marker of aluminum toxicity. Am. J. Kidney Diseases 9:217-221, 1987.
  • Burnatowska-Hledin, M.A., Spielman, W.S.: Vasopressin increases cytosolic free calcium in LLC-PK1 cells through a V1-receptor. Am. J. Physiol. 25:F328-F332, 1987.
  • Glinert, R.J., Burnatowska-Hledin, M.A.: Serum and urinary aluminum levels in patients receiving alum-precipitated allergenic extracts. Annals of Allergy 61:4o-45, 1988.
  • Burnatowska-Hledin, M.A., Spielman, W.S.: Immunodissection of mitochondria-rich cells from rabbit outer medullar collecting tubule. Am. J. Physiol. 254:F907-F911, 1988.
  • Arend, L.J., Burnatowska-Hledin, M.A., Spielman, W.S.: Adenosine signal transduction in the rabbit cortical collecting tubule: Receptor mediated calcium-mobilization. Am. J. Physiol. 255:C581-C588, 1988.
  • Allen, M.L., Sonnenberg, W.K., Burnatowska-Hledin, M.A., Spielman, W.S., Smith, W.L.: Immunodissection of cortical and medullary thick ascending limb cells from rabbit kidney. Am. J. Physiol. 255:F704-F710., 1988.
  • Burnatowska-Hledin, M.A., Spielman, W.S.: Vasopressin V1 receptors on the principal cells of the rabbit cortical collecting tubule: Stimulation of cytosolic free calcium and inositol phosphate production via coupling to a pertussis toxin substrate. J. Clin. Inv. 8:84-89, 1989.
  • Burnatowska-Hledin, M.A., Spielman, W.S.: Effects of adenosine in cyclic AMP production and cytosolic calcium in cultured rabbit medullary thick limb cells. Am. J. Physiol. 260:C141-150, 1991.
  • Bhattacharya, S., Dewitt, D.L., Burnatowska-Hledin, M., Smith W.L., Spielman, WS. Cloning of an adenosine A1 receptor-encoding gene from rabbit. Gene: 128, 285-288, 1993.
  • Burnatowska-Hledin, M.A., Spielman, W.S, Smith, W.L., Meyer, J., Shi, P., and DeWitt, D.L. Expression cloning of a calcium-linked vasopressin binding protein (VACM-1). Am. J. Physiol. 268:F1198-F1210, 1995.
  • Burnatowska-Hledin, M., Lazdins IB, Listenberger L, Zhao P, Sharangpani A, Folta V, and Card B. VACM-1 receptor is specifically expressed in rabbit vascular endothelium and renal collecting tubule. Am. J. Physiol. 276:F199-F209, 1999.
  • Burnatowska-Hledin, M., Capps B, Folta V, Zhao P, Mungall C, Sharangpani AM, nd Listenberger L. VACM-1 a cullin gene family member, regulates cellular signaling. Am. J. Physiol. 279:1266-1273, 2000.
  • Burnatowska-Hledin M, Zeneberg A, Roulo A, Grobe J, Zhao P, Lelkes PL, Clare P, Barney C. Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycle. Endothelium: 8: 49-63; 2001.
  • Van Dort C, Zhao P, Parmelee K, Capps B, Poel A, Listenberger L, Wasilevich B, Murrey J D, Kossoris J, Clare P, and and Burnatowska-Hledin M. VACM-1, a cullin gene family member, attenuates cellular growth in vitro. Am. J. Physiol. 285: C1386-C1396, 2003.
  • Burnatowska-Hledin, M. and M. DeJongh. Development and Implementation of an Introductory Bioinformatics Course at Hope College. In: Transformations @ Liberal Arts in Digital Age. Vol 2: (http://dev.colleges.org/drupal/) 2004.
  • Burnatowska-Hledin M, Kossoris J*, Van Dort C*, Murrey D*, Abbott J*, Kan C* and C. Barney. VACM-1 expression in T47D human breast cancer cell line. Biochem. Biophys. Res. Com. 319: 817-825, 2004.
  • Ashleigh Sartor*, J.B. Kossoris*, R. Wilcox, R*. Shearer*, A.E. Zeneberg*, P. Zhao, I. Lazdins and Maria A. Burnatowska-Hledin1.. Truncated form of VACM-1/cul 5 with an extended 3 untranslated region stimulates cell growth via a MAPK-dependent pathway. Biol. Biochem. Res Comm. 2006 in Press.
  • A.E. Johnson, I.P. Lee, A. Buchwalter, Maria A. Burnatowska-Hledin Estrogen-dependent growth and estrogen receptor (ER)-? concentration in T47D breast cancer cells are inhibited by VACM-1, a cul 5 gene Mol Cell Biochem, 2007, 301:13-20
  • Justin Lubbers*, Steven Lewis*, Emily Harper*, Michael P. Hledin*, Gabriel A. Marquez*, Alyssa E. Johnson*, Danelle R. Graves* and Maria A. Burnatowska-Hledin Resveratrol Enhances Anti-Proliferative Effect of VACM-1/cul5 in T47D Cancer Cells. Cell Biology and Toxicology. 2010.
  • Shirley E. Bradley*, Alyssa E. Johnson*, I. P. Le*, E. Oosterhouse*, Michael P. Hledin*, Gabriel A. Marquez* and Maria A. Burnatowska-Hledin. Phosphorylation of VACM-1/cul5 by protein kinase A regulates its neddylation and antiproliferative effect. J. Biol. Chem. 285: 4883-4895. 2010.
  • M. Short, A. Short*, R. VanKampen* and Maria A. Burnatowska-Hledin. Using HPLC_Mass Spectrometry to teach proteomics with problem-based techniques. Biochem and Molec Bio Education. 38: 242-246, 2010.
  • Alyssa E. Johnson*, I. P. Le*, A. Buchwalter* and Maria A. Burnatowska-Hledin: VACM-1, a cul-5 Gene, Regulates Estrogen Dependent Growth of T47D Cancer Cell Line. (Molec Cell Biochemistry, 301: 13-20, 2007.
  • A. Buchwalter*, C. Van Dort*, R. Smith*, S. Schultz*, I. P. Le*, J. Abbott*, E. Oosterhouse*, A. Johnson*, F. Hansen-Smith* and Maria A. Burnatowska-Hledin: Nedd-8 Modification of VACM-1/cul 5 induces MAPK phosphorylation and maspin degradation, and converts endothelial cells to the angiogenic phenotype. (Microvascular Research-75: 155-168, 2008.
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Contact Details

Phone: 616-395-7764
Fax: 616-395-7125
Email: hledin@hope.edu
Office: Science Center 3061

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Wednesdays 9:00-10:00
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