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Picture of Virginia M. Mcdonough Virginia M. Mcdonough Professor of Biology and Chair of the Biology Department

Publications

  • Vonderfecht T.R., Schroyer D.C., Schenck B.L., McDonough, V.M., Pikaart M.J. Substitution of DNA-contacting amino acids with functional variants in the Gata-1 zinc finger: A structurally and phylogenetically guided mutagenesis. Biochem Biophys Res Commun 2008 May 16;369(4):1052-6.
  • Iverson, S., Sonnemann, K., Reddick,A., McDonough, V. Expression of the S. cerevisiae PIS1 gene is modulated by multiple ATGs in the promoter. Biochem Biophys Res Commun. 2006 Nov 10;350(1):91-6.
  • Fores, O., Arro, M., Pahissa, A., Ferrero, S., Germann, M., Stukey, J. , McDonough, V., Nickels, J.T. Jr., Campos, N., Ferrer, A. Arabidopsis thaliana expresses two functional isoforms of Arvp, a protein involved in the regulation of cellular lipid homeostasis. Biochim. Biophys. Acta, 2006 Jul;1761(7):725-35.
  • Germann M, Gallo C, Donahue T, Shirzadi R, Stukey J, Lang S, Ruckenstuhl C, Oliaro-Bosso S, McDonough V, Turnowsky F, Balliano G, Nickels JT Jr. Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis. J Biol Chem. 2005 Oct 28;280(43):35904-13.
  • McDonough, V.M., Roth T. Growth temperature affects accumulation of exogenous fatty acids and fatty acid composition in Schizosaccharomyces pombe. Antonie van Leeuwenhoek. 2004. Nov;86(4):349-54.
  • McDonough, V.M., Stukey, J., Cavanagh, T. Mutations in erg4 affect the sensitivity of Saccharomyces cerevisiae to medium chain fatty acids. Biochim. Biophys. Acta. 2002. 1581 (3) pp. 109-118.
  • Swain E., Baudry K., Stukey J., McDonough V., Germann M., Nickels JT Jr. Sterol-dependent Regulation of Sphingolipid Metabolism in Saccharomyces cerevisiae. 2002. J. Biol. Chem. 277(29):26177-84.
  • Swain E, Stukey J, McDonough V, Germann M, Liu Y., Sturley S., Nickels JT Jr. Yeast Cells Lacking the ARV1 Gene Harbor Defects in Sphingolipid Metabolism: Complementation by Human hARV1. 2002. J. Biol Chem. 277(39):36152-60.
  • Nadkarni, A., McDonough, V.M., Yang, W.-L., Stukey, J., Carman, G.M. Differential Regulation of URA7 and URA8 Encoded CTP Synthetases from Saccharomyces cerevisiae. 1995. J. Biol. Chem. 270: 24982-24988.
  • McDonough, V.M., Buxeda, R., Bruno, M.E.C., Ozier-Kalogeropoulos, O., McMaster, C., Bell, R., Carman, G.M. 1995. Regulation of Phospholipid Synthesis in Saccharomyces cerevisiae by CTP. J. Biol. Chem. 270:18774-18780.
  • Wu, W.-I., McDonough, V.M., Nickels, J.T., Ko, J., Fischl, A.S., Vales, T.R., Merrill, A.H. Jr., Carman, G.M. 1995. Regulation of Lipid Biosynthesis in Saccharomyces cerevisiae by Fumonisin B1. J. Biol. Chem. 270: 13171-13178.
  • Yang, W.-L, McDonough, V.M., Ozier-Kalogeropoulos, O., Adeline M.T., Flocco M.T., Carman, G.M. 1994. Purification and Characterization of CTP Synthetase, the Product of the URA7 gene in Saccharomyces cerevisiae. Biochem. 33: 10785-10793.
  • McDonough, V.M., Stukey J.E., Martin, C.E. 1992. Specificity of Unsaturated Fatty Acid-regulated Expression of the Saccharomyces cerevisiae OLE1 Gene. J. Biol. Chem. 267: 5931-5936.
  • Stukey J.E., McDonough, V.M., Martin, C.E. 1990. The OLE1 Gene Encodes the ?9 Fatty acid Desaturase and Can be Functionally Replaced by the Rat Stearoyl-CoA Desaturase Gene. J. Biol. Chem. 265: 20144-20149.
  • Stukey J.E., McDonough, V.M., Martin, C.E. 1989. Isolation and Characterization of OLE1, a Gene Affecting Fatty Acid Desaturation From Saccharomyces cerevisiae. J. Biol. Chem. 264 (28) 16537-16544.
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Contact Details

Phone: 616-395-7715
Fax: 616-395-7125
E-mail: mcdonough@hope.edu
Office: Science Center 3009

Office Hours

By appointment.